Objective: The purpose of this study was to evaluate the correlation between bolus-tracking parameters and heart rate (HR) with attenuation of the ascending aorta and create a linear regression model for predicting coronary attenuation in coronary computed tomography angiography (CCTA).

Methods: A total of 50 patients (31 men, 19 women; mean age, 67.2±10.8 y) underwent CCTA using a 320-detector CT scanner. A bolus-tracking scan was performed to optimize the scan timing. The average HR under normal breathing for 10s was recorded just before the bolus-tracking scan started. Attenuation values of the pulmonary artery at 7s (PA7) and 10s (PA10) after the beginning of the injection were recorded during the bolus-tracking scan and the ascending aortic attenuation (CEAAo) was measured during the diagnostic scan.

Results: A positive correlation was observed between PA7 and CEAAo (r=0.41, P=0.003) and PA10 and CEAAo (r=0.66, P<0.0001), and weak negative correlation was observed between HR and CEAAo (r=-0.46, P=0.15). A multivariable linear regression model for predicting CEAAo was evaluated, and the residual error between the predicted and the measured CEAAo was within approximately ±100 HU.

Conclusions: Coronary attenuation could be predicted using HR and pulmonary artery attenuation during the bolus-tracking method.

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