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Article Synopsis
  • - SMART syndrome is a rare complication that can occur after brain radiotherapy, and this case is notable for presenting with symptoms like metamorphopsia (visual distortion) that improved with medications such as aspirin, verapamil, and high-dose L-arginine.
  • - A 43-year-old man experienced migraine headaches along with visual disturbances, which were linked to a history of high-dose radiotherapy for a brain tumor 32 years prior; MRI findings supported the diagnosis of SMART syndrome.
  • - The case highlights the need for awareness of atypical presentations of SMART syndrome in patients with neurological issues after brain radiation, underscoring the urgency for better diagnostic and treatment options.
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Background: Metastatic tumors are the most common malignancies of central nervous system in adults, and the frequent primary lesion is lung cancer. Brain and leptomeningeal metastases are more common in patients with non-small-cell lung cancer harboring epidermal growth factor receptor mutations. However, the coexist of brain metastasis with leptomeningeal metastasis (LM) in isolated gyriform appearance is rare.

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Pancreatic neuroendocrine neoplasms (PanNENs) are uncommon tumors. Fine needle aspiration (FNA) samples from PanNENs are typically of high cellularity and lack necrosis. In cytology slides from these tumors, dyscohesive cells are usually reported with variably round to oval to plasmacytoid forms exhibiting coarsely granular chromatin and showing immunoreactivity for synaptophysin.

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Background: Dengue encephalitis is a rare neurological manifestation of dengue fever. Its clinical presentation is similar to other viral encephalitides and encephalopathy. No single specific finding on magnetic resonance imaging of dengue encephalitis has yet been documented.

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Pleomorphic xanthoastrocytoma (PXA) is an uncommon tumor of young adults that typically occurs supratentorially. It is generally considered to be a low-grade, circumscribed tumor that when treated by surgical resection has a relatively favorable outcome. Cases of cerebellar PXA are rare, and those associated with neurofibromatosis type 1 (NF1) are even less common, with only 2 cases reported to date.

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