Objectives: To determine the effect of fasting immediately after exercise on blood lactate clearance.
Methods: This study was conducted at College of Medicine, Dammam University, KSA. Untrained male volunteers (n = 26) between 18-23 years of age were divided into two equal groups; fasting and non-fasting. After an overnight fasting both groups were made to exercise on a bicycle ergometer starting with 100 watt resistance with 25 watt increment after every 2 minutes until voluntary exhaustion. The fasting group was then asked to continue fasting 30 minutes after exercise, while the non-fasting group was given 600 ml of carbohydrate-rich (about 16g per 100 ml) drink immediately after exercise. We measured the blood lactate level before, immediately after, and 30 minutes after exercise in both the groups.
Results: A significant (p < 0.001) increase in mean blood lactate level was observed in both the groups immediately after exercise as compared to the baseline means. Similarly there was a significant (p < 0.001) drop of lactate level in both the groups 30 minutes after exercise as compared with the blood lactate level immediately after exercise. There was a significant (p < 0.001) difference between the number of subjects with a blood lactate drop of more than 50% between the two groups (84.61% of subjects in the fasting group, versus 46.15% in the non-fasting group).
Conclusion: Fasting after exercise accelerates lactate clearance from blood, probably by utilizing gluconeogenesis pathway.
Download full-text PDF |
Source |
---|
Asian J Transfus Sci
August 2024
Department of Immunohematology and Transfusion Medicine, Santokba Durlabhji Memorial Hospital, Jaipur, Rajasthan, India.
Drug-induced hemolytic anemia (DIHA) is a rare but significant condition characterized by the premature destruction of red blood cells (RBCs) triggered by certain medications. Ceftriaxone, a commonly used antibiotic, has been linked to DIHA, presenting diagnostic challenges due to its diverse clinical manifestations. This study examines three cases of DIHA caused by ceftriaxone therapy at our center.
View Article and Find Full Text PDFSci Rep
January 2025
Emergency Trauma Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, China.
To measure the correlation and agreement between arterial and peripheral venous blood lactate in the emergency room and to assess the predictive value of lactate for the occurrence of cardiac arrest. This was a retrospective cohort study involving 784 patients from January 1, 2020, to July 31, 2021, in the Emergency Room of the First Affiliated Hospital of Xinjiang Medical University. General information, vital signs, clinical symptoms, and laboratory findings of the patient were collected.
View Article and Find Full Text PDFBMC Sports Sci Med Rehabil
January 2025
Department of Pharmacy, The 969 th Hospital of P.L.A, Hohhot, 010051, China.
Background: Heat stroke, a severe heat illness with organ damage, is a major cause of cause irreparable organ damage and higher death rates among military persons and athletes.
Objectives: To study the changes in blood lactate (Lac) levels and lactate clearance rate (LCR) in athletes with heat illness of varying degrees after high-intensity exercise and to evaluate their prognostic value.
Material And Methods: In present study, acute care unit admitted 36 heat sickness patients following high-intensity exercise from December 2019 to July 2024, with comprehensive medical records, for retrospective study.
Crit Care
January 2025
Center of Clinical Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing, Jiangsu, China.
Despite intensive clinical and scientific efforts, the mortality rate of sepsis remains high due to the lack of precise biomarkers for patient stratification and therapeutic guidance. Interleukin 40 (IL-40), a novel cytokine with immune regulatory functions in human diseases, was elevated at admission in two independent cohorts of patients with sepsis. High levels of secreted IL-40 in septic patients were positively correlated with PCT, CRP, lactate (LDH), and Sequential Organ Failure Assessment (SOFA) scores, in which IL-40 levels were used to stratify the early death of critically ill patients with sepsis.
View Article and Find Full Text PDFCurr Med Chem
January 2025
Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Kherva, 384012, India.
Aims: This study aimed to develop Imatinib Mesylate (IMT)-loaded Poly Lactic-co-Glycolic Acid (PLGA)-D-α-tocopheryl polyethylene glycol succinate (TPGS)- Polyethylene glycol (PEG) hybrid nanoparticles (CSLHNPs) with optimized physicochemical properties for targeted delivery to glioblastoma multiforme.
Background: Glioblastoma multiforme (GBM) is the most destructive type of brain tumor with several complications. Currently, most treatments for drug delivery for this disease face challenges due to the poor blood-brain barrier (BBB) and lack of site-specific delivery.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!