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Utilizing transmembrane convection to enhance solute sampling and delivery by microdialysis: theory and in vitro validation.
J Memb Sci
February 2010
Laboratory of Bioengineering and Physical Science, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892.
Microdialysis is a well-developed membrane-based tool relying on diffusion to sample diffusible constituents of complex media, such as biological tissue. The objective of this research is to expand the utility of microdialysis by combining transmembrane convection with diffusion to enhance solute exchange between microdialysis probes and the surrounding medium. We have developed a mathematical model to describe probe performance and performed validation experiments utilizing tracer solutes and commercially available probes with 100-kDa molecular weight cutoff membranes.
View Article and Find Full Text PDFFor some time the subcutaneous (s.c.) tissue has been the target for continuous glucose measurement.
View Article and Find Full Text PDFMicrodialysis--theory and application.
Prog Neurobiol
December 1990
Department of Medicine, Duke University Medical Center, Durham, NC 27710.
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