AI Article Synopsis
- * A study found that children with non-lesional TLE had higher serum Bcl-2 levels compared to healthy controls, correlating with factors like seizure duration, frequency, and severity.
- * Lower IQ scores in children with TLE also showed a negative correlation with Bcl-2 levels, suggesting that Bcl-2 could serve as an indicator of both seizure impact and cognitive function in these patients.
Article Abstract
Intractable temporal lobe epilepsy (TLE) is associated with alterations in expression of apoptosis-associated signaling molecules in the temporal lobe. Bcl-2 is an anti-apoptotic molecule which has previously been reported to be raised in patient's brain and serum. In the present study we examined serum Bcl-2 protein levels as a surrogate marker of apoptosis-associated signaling in children with non lesional TLE. Serum Bcl-2 levels were found to be higher in patients with TLE than controls. The serum level correlated to seizure variables including, duration of disease, frequency of seizures, and disease severity. The impact of epilepsy on cognition was assessed using total score intelligence quotient (IQ). IQ was found to be lower than controls and negatively correlated to serum Bcl-2. These findings support serum Bcl-2 levels as a marker of seizure burden and cognition in children with epilepsy.
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| http://dx.doi.org/10.1016/j.seizure.2012.01.004 | DOI Listing |
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