Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.lpm.2012.01.017 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Unlabelled: Immune escape is a critical hallmark of cancer progression and underlies resistance to multiple immunotherapies. However, it remains unclear when the genetic events associated with immune escape occur during cancer development. Here, we integrate functional genomics studies of immunomodulatory genes with a tumor evolution reconstruction approach to infer the evolution of immune escape across 38 cancer types from the Pan-Cancer Analysis of Whole Genomes dataset.
View Article and Find Full Text PDFA previous study found that a domesticated bacterial group II intron-like reverse transcriptase (G2L4 RT) functions in double-strand break repair (DSBR) via microhomology-mediated end joining (MMEJ) and that a mobile group II intron-encoded RT has a basal DSBR activity that uses conserved structural features of non-LTR-retroelement RTs. Here, we determined G2L4 RT apoenzyme and snap-back DNA synthesis structures revealing novel structural adaptations that optimized its cellular function in DSBR. These included a unique RT3a structure that stabilizes the apoenzyme in an inactive conformation until encountering an appropriate substrate; a longer N-terminal extension/RT0-loop with conserved residues that together with a modified active site favors strand annealing; and a conserved dimer interface that localizes G2L4 RT homodimers to DSBR sites with both monomers positioned for MMEJ.
View Article and Find Full Text PDFLithospheric strike-slip faulting in central Tibet since 35-32 Ma and implications for the incipient Asian extrusional tectonics.
Natl Sci Rev
February 2025
SinoProbe Laboratory, Key Laboratory of Continental Dynamics of Ministry of Natural Resources, Institute of Geology, Chinese Academy of Geological Sciences, Beijing 100037, China.
The onset age and depth of the central Tibet strike-slip faults are two still unresolved fundamental issues with regard to the Cenozoic tectonic evolution of central Tibet. Here we present a comprehensive dataset of geochronological, geochemical and structural data on recently discovered en-echelon dykes representing the incipient development of strike-slip faulting from the Lunpola basin in central Tibet. Our results provide evidence for mantle-derived, bimodal magmatism linked to lithospheric-scale strike-slip faulting at 35-32 Ma, and demonstrate that the central Tibet strike-slip faults are at least 20 Ma older than previously estimated (15-8 Ma).
View Article and Find Full Text PDFDesign Criteria for Active and Selective Catalysts in the Nitrogen Oxidation Reaction.
ACS Phys Chem Au
January 2025
University of Duisburg-Essen, Faculty of Chemistry, Theoretical Catalysis and Electrochemistry, Universitätsstraße 5, Essen 45141, Germany.
The direct conversion of dinitrogen to nitrate is a dream reaction to combine the Haber-Bosch and Ostwald processes as well as steam reforming using electrochemistry in a single process. Regrettably, the corresponding nitrogen oxidation (NOR) reaction is hampered by a selectivity problem, since the oxygen evolution reaction (OER) is both thermodynamically and kinetically favored in the same potential range. This opens the search for the identification of active and selective NOR catalysts to enable nitrate production under anodic reaction conditions.
View Article and Find Full Text PDFCoS/CoTe n-n Type Heterojunction: A Heterogenic Interfacial Integration of CoS and CoTe Phases for Energy-Efficient Hydrazine Oxidation Assisted Hydrogen Production.
Small
January 2025
Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, West Bengal, 741246, India.
Controlled and optimized heterogenic interfacial coupling is the key to enhance the electrochemical performance. Herein, for the first time, telluride-based CoS/CoTe heterostructure is reported as a bifunctional catalyst for energy-efficient H generation. Detailed investigations suggest that the heterogenic interfacial coupling leads to superior bifunctional electrochemical performance of the CoS/CoTe heterostructure.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!