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Astragaloside IV Relieves Central Sensitization by Regulating Astrocytic ROS/NF-κB Nuclear Translocation Signaling in Chronic Migraine Male Rats.
Phytother Res
January 2025
Laboratory Research Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Chronic migraine (CM) is a disabling neurological disease. Astragaloside IV (AS-IV), a natural product derived from Astragalus membranaceus, shows great potential in treating chronic pain by relieving inflammation and oxidative stress. This study aimed to investigate the effects and mechanisms of action of AS-IV on CM.
View Article and Find Full Text PDFMetagenomic and metabolomic profiling analyses to unravel the formation mechanism of n-propanol during the first and second round of Jiangxiangxing Baijiu fermentation.
Food Res Int
January 2025
College of Bioengineering, Tianjin University of Science and Technology, Thirteenth Street, Binhai New District, Tianjin 300457, China; Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Thirteenth Street, Binhai New District, Tianjin 300457, China; Liquor Making Biological Technology and Application of Key Laboratory of Sichuan Province, Sichuan, China. Electronic address:
N-propanol is one of the higher alcohols, a moderate amount of n-propanol is beneficial for the harmony of the liquor body, whereas excessive or repeated intake will lead to discomfort and pose significant harm to human health. In actual production process of Jiangxiangxing Baijiu, the n-propanol content of the base baijiu in first round (FR) is far higher than that of second round (SR). Nevertheless, the formation mechanism and the key n-propanol producing microbials remain unclear and this limits the quality control of baijiu fermentation.
View Article and Find Full Text PDFPredicting the decline of physical function among the older adults in China: A cohort study based on China longitudinal health and longevity survey (CLHLS).
Geriatr Nurs
November 2024
School of Public Health, Chongqing Medical University, Chongqing, PR China. Electronic address:
Background: As the arrival of healthy aging, maintaining physical function (PF) in older adults is crucial for their health, so it is necessary to detect the decline of PF among them and take intervention measures.
Methods: We construct eight machine learning models to predict declines of PF in this study. The performance of the models was tested by Area Under Curve (AUC), sensitivity, specificity, accuracy, precision-recall (PR) curve and calibration degree.
Regulation of seed soaking with indole-3-butyric acid potassium salt (IBA-K) on rapeseed (Brassica napus L.) seedlings under NaCl stress.
BMC Plant Biol
September 2024
Binhai Agriculture College, Guangdong Ocean University, Zhanjiang, 524088, China.
The growth and yield of rapeseed are significantly hampered by salt stress. Indole-3-butyric Acid Potassium Salt (IBA-K) has been found to alleviate the impact of salt stress on plant growth. However, the regulatory effect of IBA-K dipping on salt-stressed rapeseed remains unclear.
View Article and Find Full Text PDFThermo-responsive cascade antimicrobial platform for precise biofilm removal and enhanced wound healing.
Burns Trauma
September 2024
Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, No. 38 Tongyan Road, Haihe Education Park, Jinnan District, Tianjin 300071, PR China.
Article Synopsis
- - The study develops a multifunctional nanosystem called HMAPH to tackle issues related to bacterial infections and wound healing by utilizing a combination of materials including methylene blue and gold particles to enhance the therapeutic effects of photodynamic therapy.
- - HMAPH’s performance is analyzed through various scientific techniques, demonstrating its capability to release iron ions and generate reactive hydroxyl radicals, which are effective in killing bacteria when activated by light.
- - The efficacy of HMAPH in promoting wound healing and reducing inflammation is validated through experiments on an infected mouse model, showing improved outcomes in tissue repair and infection control.
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