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The chemical investigation of an Indonesian specimen of Theonella swinhoei afforded four aurantosides, one of which, aurantoside J (5), is a new compound. The structure of this metabolite, exhibiting the unprecedented N-α-glycosidic linkage between the pentose and the tetramate units, has been determined through detailed spectroscopic analysis. The four obtained aurantosides have been tested against five fungal strains (four Candida and one Fusarium) responsible of invasive infections in immuno-compromised patients. The non-cytotoxic aurantoside I (4) was the single compound to show an excellent potency against all the tested strains, thus providing valuable insights about the antifungal potential of this class of compounds and the structure-activity relationships.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280571 | PMC |
| http://dx.doi.org/10.3390/md9122809 | DOI Listing |
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Article Synopsis
- Scientists are discovering that bacteria in sponges can create important chemicals that help protect the sponge and contribute to its health.
- A new method called MERMAID helps researchers find and study these bacteria, even the ones that are hard to grow in labs.
- By using this method, they discovered a specific bacteria called 'Poriflexus aureus' that produces a special antifungal chemical, showing that sponges have even more useful bacteria than we thought!
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