AI Article Synopsis
- A chemical study of the Red Sea soft coral Sarcophyton glaucum resulted in the discovery of two new peroxide diterpenes and a compound called 8-epi-sarcophinone.
- Researchers also identified two known compounds, ent-sarcophine and sarcophine, through spectroscopic analysis and confirmed their structures using X-ray diffraction.
- The isolated compounds showed potential in inhibiting certain enzyme activities and inducing protective enzymes, highlighting their possible role in cancer prevention.
Article Abstract
A chemical investigation of an ethyl acetate extract of the Red Sea soft coral Sarcophyton glaucum has led to the isolation of two peroxide diterpenes, 11(S) hydroperoxylsarcoph-12(20)-ene (1), and 12(S)-hydroperoxylsarcoph-10-ene (2), as well as 8-epi-sarcophinone (3). In addition to these three new compounds, two known structures were identified including: ent-sarcophine (4) and sarcophine (5). Structures were elucidated by spectroscopic analysis, with the relative configuration of 1 and 2 confirmed by X-ray diffraction. Isolated compounds were found to be inhibitors of cytochrome P₄₅₀ 1A activity as well as inducers of glutathione S-transferases (GST), quinone reductase (QR), and epoxide hydrolase (mEH) establishing chemo-preventive and tumor anti-initiating activity for these characterized metabolites.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280536 | PMC |
| http://dx.doi.org/10.3390/md10010209 | DOI Listing |
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