AI Article Synopsis
- A new compound called aurantoside K was discovered in a marine sponge from the Melophlus genus.
- The structure of aurantoside K was determined using various advanced spectroscopy techniques.
- While it showed no significant activity against malaria, bacteria, or cancer cells, it displayed strong antifungal effects against several types of fungi, including different strains of Candida and Aspergillus.
Article Abstract
A new tetramic acid glycoside, aurantoside K, was isolated from a marine sponge belonging to the genus Melophlus. The structure of the compound was elucidated on the basis of spectroscopic analysis (¹H NMR, ¹H-¹H COSY, HSQC, and HMBC, as well as high-resolution ESILCMS). Aurantoside K did not show any significant activity in antimalarial, antibacterial, or HCT-116 cytotoxicity assays, but exhibited a wide spectrum of antifungal activity against wild type Candida albicans, amphotericin-resistant C. albicans, Cryptococcus neoformans, Aspergillus niger, Penicillium sp., Rhizopus sporangia and Sordaria sp.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280539 | PMC |
| http://dx.doi.org/10.3390/md10010200 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A plug-and-play system for polycyclic tetramate macrolactam production and functionalization.
Microb Cell Fact
January 2025
Chair of Technical Biochemistry, Technische Universität Dresden, Bergstraße 66, 01069, Dresden, Germany.
Background: The biosynthesis of the natural product family of the polycyclic tetramate macrolactams (PoTeMs) employs an uncommon iterative polyketide synthase/non-ribosomal peptide synthetase (iPKS/NRPS). This machinery produces a universal PoTeM biosynthetic precursor that contains a tetramic acid moiety connected to two unsaturated polyene side chains. The enormous structural and hence functional diversity of PoTeMs is enabled by pathway-specific tailoring enzymes, particularly cyclization-catalyzing oxidases that process the polyene chains to form distinct ring systems, and further modifying enzymes.
View Article and Find Full Text PDFIntegrated Approach to Cyclopiazonic Acid Cytotoxicity Using (2D and 3D Models) and Methods.
Toxins (Basel)
November 2024
Department of Preventive Medicine and Public Health, Food Science, Toxicology and Forensic Medicine, Faculty of Pharmacy and Food Science, University of Valencia, Av. Vicent A Estelles s/n, Burjassot, 46100 Valencia, Spain.
Cyclopiazonic acid (CPA) is an indole-tetramic acid neurotoxin produced by and genera present mainly in fruit, cereals and nuts. This study compares the cytotoxicity produced by CPA after 24, 48 and 72 h of exposure using both monolayers and 3D spheroids in human neuroblastoma SH-SY5Y cells. Furthermore, CPA toxicokinetics was evaluated using models.
View Article and Find Full Text PDFSemisynthetic Tetramate-Containing Fungal Metabolites with Activity against and .
ACS Med Chem Lett
November 2024
Natural Products Discovery Group, Institute for Natural Products Applications and Research Technologies, Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, Oklahoma 73019, United States.
Tetramic acid-containing natural products are well known for their promising biological activity against various diseases. In our previous study, we reported fungal-derived tetramic acid-containing natural products with activity against . Here, we demonstrate that is also highly susceptible to this chemotype and we uncovered the initial structure activity relationships on disparate tetramate chemotypes in phomasetin () and pyrrolocin A ().
View Article and Find Full Text PDFLipid Metabolism as a Target Site in Pest Control.
Adv Exp Med Biol
October 2024
Bayer AG, Crop Science Division, Monheim, Germany.
Lipid metabolism is essential to insect life as insects use lipids for their development, reproduction, flight, diapause, and a wide range of other functions. The central organ for insect lipid metabolism is the fat body, which is analogous to mammalian adipose tissue and liver, albeit less structured. Various other systems including the midgut, brain, and neural organs also contribute functionally to insect lipid metabolism.
View Article and Find Full Text PDFSteroids and Epicoccarines from .
Phytochem Lett
October 2024
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
Lichens are symbiotic organisms comprised of mycobionts and photobiont partners. They are known to produce bioactive secondary metabolites and most of these are biosynthesized by mycobionts. Investigations of cultures of isolated lichen-associated fungi have shown promise for the discovery of cytotoxic compounds.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!