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Effect of PGD on middle meningeal artery and mRNA expression profile of L-PGD synthase and DP receptors in trigeminovascular system and other pain processing structures in rat brain.
Pharmacol Rep
February 2017
Department of Neurology, Rigshospitalet-Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Electronic address:
Background: Prostaglandins (PGs), particularly prostaglandin D (PGD), E (PGE), and I (PGI), are considered to play a role in migraine pain. In humans, infusion of PGD causes lesser headache as compared to infusion of PGE and PGI. Follow-up studies in rats have shown that infusion of PGE and PGI dilate the middle meningeal artery (MMA), and mRNA for PGE and PGI receptors is present in rat trigeminovascular system (TVS) and in the brain structures associated with pain.
View Article and Find Full Text PDF[Sleep-wake regulation by prostaglandin D2 and adenosine].
Brain Nerve
June 2012
Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Japan.
Prostaglandin (PG) D2 and adenosine are potent endogenous somnogens that accumulate in the brain during prolonged wakefulness. Lipocalin-type PGD synthase (L-PGDS) catalyzes the isomerization of PGH2, a common precursor of various prostanoids, to produce PGD2. L-PGDS is localized in the leptomeninges, choroid plexus, and oligodendrocytes of the central nervous system.
View Article and Find Full Text PDFEndogenous N-acyl-dopamines induce COX-2 expression in brain endothelial cells by stabilizing mRNA through a p38 dependent pathway.
Biochem Pharmacol
June 2010
Departamento de Biología Celular, Fisiología e Inmunología, Universidad de Córdoba. Facultad de Medicina. Avda de Menéndez Pidal s/n, 14004 Córdoba, Spain.
Cerebral microvascular endothelial cells play an active role in maintaining cerebral blood flow, microvascular tone and blood brain barrier (BBB) functions. Endogenous N-acyl-dopamines like N-arachidonoyl-dopamine (NADA) and N-oleoyl-dopamine (OLDA) have been recently identified as a new class of brain neurotransmitters sharing endocannabinoid and endovanilloid biological activities. Endocannabinoids are released in response to pathogenic insults and may play an important role in neuroprotection.
View Article and Find Full Text PDFProstaglandin (PG)D(2) and 15-deoxy-Delta(12,14)-PGJ(2), but not PGE(2), mediate shear-induced chondrocyte apoptosis via protein kinase A-dependent regulation of polo-like kinases.
Cell Death Differ
August 2010
Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Excessive mechanical loading of cartilage producing hydrostatic stress, tensile strain and fluid flow leads to chondrocyte apoptosis and osteoarthritis. High fluid flow induces cyclooxygenase-2 (COX-2) expression in sheared chondrocytes, which suppresses their antioxidant capacity and contributes to apoptosis. The pivotal role of COX-2 in shear-induced chondrocyte apoptosis and the conflicting literature data on the roles of prostaglandin (PG)E(2), PGD(2) and its metabolite 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) in chondrocyte apoptosis prompted us to analyze which COX-2-derived PG is involved in this process.
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