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Purpose: To investigate the association between blepharoptosis (ptosis) and psychosocial stress levels, depression, and anxiety in a diverse population of American adults.
Methods: Utilizing data from the National Institutes of Health's All of Us Research Program, we analyzed responses from 104,456 participants who completed psychosocial assessments. Participants with a history of a ptosis diagnosis were 1:3 matched with controls using propensity score calculated based on demographics and comorbidities.
Botulinum Toxin: A Non-surgical Approach for Non-myasthenic Mild-to-Moderate Blepharoptosis Treatment.
Aesthetic Plast Surg
December 2024
Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, 00128, Roma, Italy.
Article Synopsis
- Mild-to-moderate blepharoptosis can negatively impact appearance, with some patients hesitant to pursue surgery; Botulinum neurotoxin A (BoNT-A) injections offer a non-surgical alternative.
- A study included 49 patients (39 females, 10 males) with various causes of eyelid ptosis, using BoNT-A injections and measuring outcomes through MRD-1 changes and patient questionnaires at multiple intervals.
- Results showed significant eyelid elevation post-treatment, with most patients experiencing improvement and a high willingness to repeat the procedure, although the effects diminished after 24 weeks.
Effective encoder-decoder network for pupil light reflex segmentation in facial photographs of ptosis patients.
Sci Rep
October 2024
Department of Artificial Intelligence, Chung-Ang University, Seoul, Korea.
Accurate segmentation of pupil light reflexes is essential for the reliable assessment of ptosis severity, a condition characterized by the drooping of the upper eyelid. This study introduces a novel encoder-decoder network specialized in reflex segmentation by focusing on addressing issues related to very small regions of interest from an architectural perspective. Specifically, the proposed network is designed to exploit low-level features effectively by integrating a multi-level skip connection and a 1 × 1 convolution-enhanced initial encoding stage.
View Article and Find Full Text PDFUnraveling the Spectrum of Ocular Toxicity with Oxaliplatin: Clinical Feature Analysis of Cases and Pharmacovigilance Assessment of the US Food and Drug Administration Adverse Event Reporting System Database.
Clin Ther
December 2024
Department of Pharmacy, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address:
Article Synopsis
- This study investigates ocular adverse events (oAEs) linked to oxaliplatin, a chemotherapy drug, through a systematic review of case reports and analysis of patient data.
- Out of 20 reported cases, a majority (84.2%) experienced loss of vision, with other symptoms including eyelid conditions and optic disc swelling; about 4.28% of oxaliplatin-related adverse event reports involved these ocular issues, with a high rate of serious outcomes.
- The analysis also identified significant safety signals for various unexpected ocular injuries, indicating a need for increased awareness of these potential adverse effects among healthcare providers and patients.
Upper eyelid lymphatic anatomy is associated with blepharoplasty recovery.
J Plast Reconstr Aesthet Surg
December 2024
Department of Plastic and Reconstructive Surgery, Shinshu University School of Medicine, 3-1-1 Asahi Matsumoto, Nagano 390-8621, Japan.
Article Synopsis
- Lymphatic vessels play a key role in wound healing and fluid absorption, and this study explored how their density in eyelid tissue affects recovery after blepharoplasty.
- The research involved 40 eyelids from 21 patients, analyzing tissue samples to determine the amounts of lymphatic vessels and elastic fibers, and assessing healing through various scales at several time points post-surgery.
- Results indicated that as patients age, lymphatic vessel density decreases, especially on the medial side of the eyelid, and higher densities correlate with better healing outcomes, particularly in reducing scarring.
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