The sensomotor brain cortex of 30-day ratlings born by preliminary neurosensitized females, was studied. The studies demonstrated retardation in the development of the brain cortex in the progeny. Electon microscopic examinations detected certain features in the structure of cellular organella, as well as membrane formations in the nuclei of the cortical neurons. These changes are considered as an expression of a lowered level of neuron functioning.
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Toxicology
December 2024
Department of Zoology, IIS (Deemed to be University), Jaipur, Rajasthan, India.
In the present study, co-parental exposure to polystyrene nanoplastics (PS-NPs) elicits profound teratological impacts, including skeletal and visceral malformations, post-natal effects on neonatal growth and neurobehavioral development in F1 progeny. A comprehensive investigation was conducted on Swiss albino mice fetuses, neonates (PND 1-21) and adult mice offsprings (PND 60) following parental exposure during spermatogenesis and oogenesis period, as well as continued maternal exposure during gestation and weaning. The parental mice were administered PS-NPs via oral gavage at low dose (0.
View Article and Find Full Text PDFMetab Brain Dis
December 2024
School of Medicine, Jiangsu University, Zhenjiang, Jiangsu Province, 212013, PR China.
Schizophrenia is a kind of neurodevelopmental mental disorder in which patients begin to experience changes early in their development, typically manifesting around or after puberty and has a fluctuating course. Environmental disturbances during adolescence may be a risk factor for schizophrenia-like deficits. As a better treatment option, preventive intervention prior to schizophrenia may be more beneficial than direct treatment.
View Article and Find Full Text PDFCereb Cortex
November 2024
Brain Function Laboratory, National Institute of Genetics, SOKENDAI, 1111 Yata, Mishima, Shizuoka 411-8540, Japan.
Toxicology
December 2024
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address:
Benzophenone-3 (BP-3), commonly used in personal care products, is routinely detected in environmental and human matrices. Evidence delineates a correlation between gestational BP-3 exposure and emotional and social disorders in children and adolescents. However, sensitive target cells and the mode of action underlying the early responses to environmentally relevant level of BP-3 exposure remain unclear.
View Article and Find Full Text PDFTransl Psychiatry
September 2024
Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing, 211166, China.
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