Simultaneous thin-layer chromatography-densitometric analysis of sibutramine and citalopram.

Folia Med (Plovdiv)

Department of Pharmaceutical Sciences, Faculty of Pharmacy, Medical University, Sofia, Bulgaria.

Published: March 2012

Due the presence of sibutramine and citalopram in a number of drugs, neurotransmitter reuptake inhibitors. Sibutramine reduces the reuptake of serotonin, norepinephrine, and dopamine; citalopram is an antidepressant drug of the selective serotonin reuptake inhibitor. The thin-layer chromatography-densitometric behavior of some centrally acting serotonin reuptake inhibitors has been studied. The proposed analytical method is suitable for qualitative and quantitative analysis of sibutramine and citalopram.

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http://dx.doi.org/10.2478/v10153-011-0059-9DOI Listing

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