Due the presence of sibutramine and citalopram in a number of drugs, neurotransmitter reuptake inhibitors. Sibutramine reduces the reuptake of serotonin, norepinephrine, and dopamine; citalopram is an antidepressant drug of the selective serotonin reuptake inhibitor. The thin-layer chromatography-densitometric behavior of some centrally acting serotonin reuptake inhibitors has been studied. The proposed analytical method is suitable for qualitative and quantitative analysis of sibutramine and citalopram.
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http://dx.doi.org/10.2478/v10153-011-0059-9 | DOI Listing |
JAMA Psychiatry
August 2014
Center for Experimental Drugs and Diagnostics, Department of Psychiatry, Massachusetts General Hospital, Boston2Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Boston.
Importance: Short-term studies suggest antidepressants are associated with modest weight gain but little is known about longer-term effects and differences between individual medications in general clinical populations.
Objective: To estimate weight gain associated with specific antidepressants over the 12 months following initial prescription in a large and diverse clinical population.
Design, Setting, And Participants: We identified 22,610 adult patients who began receiving a medication of interest with available weight data in a large New England health care system, including 2 academic medical centers and affiliated outpatient primary and specialty care clinics.
Eur J Pharmacol
August 2014
Department of Neuroscience Biology, Research and Development, 5 Research Parkway, Bristol-Myers Squibb, Wallingford, CT 06492-7660, USA.
Sibutramine was formerly marketed as an anti-obesity agent. The current study investigated the relationships between monoamine reuptake site occupancy for sibutramine and both its antidepressant-like efficacy and thermogenic effects. Sibutramine's effects on locomotor activity (LMA) and food intake were also evaluated.
View Article and Find Full Text PDFFolia Med (Plovdiv)
March 2012
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Medical University, Sofia, Bulgaria.
Due the presence of sibutramine and citalopram in a number of drugs, neurotransmitter reuptake inhibitors. Sibutramine reduces the reuptake of serotonin, norepinephrine, and dopamine; citalopram is an antidepressant drug of the selective serotonin reuptake inhibitor. The thin-layer chromatography-densitometric behavior of some centrally acting serotonin reuptake inhibitors has been studied.
View Article and Find Full Text PDFDtsch Arztebl Int
March 2009
Giftinformationszentrum Nord, Zentrum Pharmakologie und Toxikologie Göttingen, Germany.
Background: In recent years, the market for dietary supplements has grown. International products are readily available for purchase over the Internet. We report 17 cases of poisoning with a single product, said to be of purely herbal origin, that was bought over the Internet.
View Article and Find Full Text PDFCurr Drug Targets
April 2004
Obesity and Eating Disorders Group--Institute of Psychiatry, Federal University of Rio de Janeiro and Institute of Endocrinology and Diabetes of Rio de Janeiro, Brazil.
Binge eating disorder (BED) is a newly defined diagnostic category characterized by recurrent episodes of binge eating not followed by the inappropriate compensatory weight loss behaviors characteristic of bulimia nervosa. BED is usually associated with overweight or obesity and psychopathology. Pharmacotherapy may be a useful component of a multidimensional treatment approach.
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