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Depressive Symptoms and Amyloid Pathology.
JAMA Psychiatry
January 2025
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Importance: Depressive symptoms are associated with cognitive decline in older individuals. Uncertainty about underlying mechanisms hampers diagnostic and therapeutic efforts. This large-scale study aimed to elucidate the association between depressive symptoms and amyloid pathology.
View Article and Find Full Text PDFEpileptic variant in the spectrum of Alzheimer's disease - practical implications.
Seizure
September 2024
Centre Mémoire, de Ressources et de Recherche de Strasbourg, France; Unité de Neuropsychologie, Service de Neurologie des Hôpitaux Universitaires de Strasbourg, Strasbourg, France; University of Strasbourg and CNRS, ICube laboratory UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg), team IMIS/Neurocrypto Strasbourg, France; Centre de Compétences des démences rares des Hôpitaux Universitaires de Strasbourg, France. Electronic address:
Article Synopsis
- Alzheimer's disease (AD) is linked to a higher risk of epilepsy, not only in its advanced stages (dementia) but also during earlier phases like mild cognitive impairment.
- Epileptic seizures can even appear in the preclinical stage of AD, leading to a specific condition called the epileptic variant of Alzheimer's disease (evAD), which may be the only visible sign of the disease at that time.
- Diagnosing evAD relies on examining amyloid and tau biomarkers and represents a crucial opportunity for early intervention with antiseizure medications to help slow down cognitive decline associated with AD.
On prior visual experience in mental map navigation using allocentric and egocentric perspectives in the visually impaired.
Q J Exp Psychol (Hove)
October 2024
Institut Jean Le Rond d'Alembert, UMR 7190, Sorbonne Université, CNRS, Paris, France.
Using new developments in the mental comparison task paradigm, this study addresses the question of the influence of prior visual experience in the natural use of mental perspective to achieve mental spatial tasks without any protocol-imposed perspective. During the experiment, 39 participants (11 early blind, 13 late blind, and 15 blindfolded-sighted) explored two corridor maps to memorise the spatial arrangement of 10 objects disposed along corridors. After the learning phase, several tasks addressing spatial memory and reasoning used in the mental spatial representation were performed.
View Article and Find Full Text PDFBreaking Taboos: Arab Breast Cancer Activism in Art and Popular Culture.
J Med Humanit
December 2024
School of Modern Languages and Cultures, Durham University, New Elvet, Elvet Riverside, Durham, DH1 3JT, UK.
This essay examines the breast cancer accounts of four Arab female celebrities who have spoken out in public about their illness experience: the Egyptian TV presenter Basma Wahba and the actress Yasmine Ghaith, the Iraqi actress Namaa al-Ward, and the Lebanese pop singer Elissa. By reading their testimonies against the backdrop of critical literature on illness narratives and memoirs, as well as on cancer narratives and activism, the essay asks: how are the accounts of these women's cancer diagnosis and treatment disclosed and described? In what medium do they communicate and circulate their breast cancer experiences? What significance do these public disclosures have on challenging and breaking the Arab taboo of cancer? In conclusion, the essay argues that these women's willingness to share their stories in public constitutes an important form of multimedia activist intervention-visual, sonic, and performative-that is playing a key role in the development of a breast cancer movement.
View Article and Find Full Text PDFYouth-like brain activation linked with greater cognitive training gains in older adults: Insights from the ACTOP study.
Cortex
July 2024
Research Center, Institut Universitaire de gériatrie de Montréal, Montreal, QC, Canada; Department of Psychology, Université de Montréal, Montreal, QC, Canada; Faculty of Medicine, Université de Montréal, Montreal, QC, Canada. Electronic address:
Article Synopsis
- A study looked at how the brains of older adults work differently and how this affects their ability to improve in memory training.
- Thirty older people did training sessions to see how well they could remember things, and their progress was tracked over time.
- The results showed that older adults whose brain activity looked more like younger people's had more success in improving their memory skills after training.
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