AI Article Synopsis
- A series of disubstituted 1,8-diamidoanthraquinones were created and tested for their ability to inhibit cell growth, telomerase activity, and hTERT expression.
- All compounds except 3a and 3s were chosen for further study by the NCI screening system.
- Notably, compounds 4e and 4k showed an ability to inhibit telomerase activity, suggesting that their effects on cell toxicity and telomerase inhibition could help in developing strategies that target telomerase.
Article Abstract
A series of symmetrical disubstituded 1,8-diamidoanthraquinones were synthesized and evaluated for anti-proliferation, telomerase inhibitory by TRAP assay, and hTERT expression by SEAP assay. All of the compounds tested, except for compounds 3a and 3s were selected by the NCI screening system. In addition, compounds 4e and 4k exhibited inhibitory effects on telomerase activity. Taken together, our findings indicated that the analysis of cytotoxicity and telomerase inhibition might provide information applicable for further developing potential telomerase targeting strategy.
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| http://dx.doi.org/10.1016/j.ejmech.2012.01.044 | DOI Listing |
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