Virtual Basic Laparoscopic Skills Trainer (VBLaST) is a virtual reality trainer that replicates the Fundamentals of Laparoscopic Surgery (FLS) tasks for training in minimally invasive surgery. For the ligation loop task, we have developed a novel hardware interface using a linear motion stroke potentiometer to accurately sense the linear translation of the ligation loop and a mechanism to attach the tool interface to a PHANToM Omni for force feedback. Testing shows that the interface provided a realistic feel and control of the loop similar to the endoloop device used in FLS ligation loop task.
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Microbiol Spectr
December 2024
Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, Kentucky, USA.
Unlabelled: are facultative intracellular bacterial pathogens that cause foodborne disease in humans. The bacteria can use the surface protein InlA to invade intestinal epithelial cells or transcytose across M cells in the gut, but it is not well understood how the bacteria traffic from the underlying lamina propria to the draining mesenteric lymph nodes (MLN). Previous studies indicated that associated with both monocytes and dendritic cells in the intestinal lamina propria.
View Article and Find Full Text PDFChem Biol Interact
January 2025
Molecular Biomedicine Laboratory, Postgraduate Department of Studies and Research in Biotechnology, Sahyadri Science College, Kuvempu University, Shivamogga, 577203, Karnataka, India. Electronic address:
Talanta
March 2025
Beijing Key Laboratory for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, 30 Xueyuan Road, Haidian District, Beijing, 100083, China. Electronic address:
Angew Chem Int Ed Engl
November 2024
Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637, USA.
The prebiotic formation of RNA building blocks is well-supported experimentally, yet the emergence of sequence- and structure-specific RNA oligomers is generally attributed to biological selection via Darwinian evolution rather than prebiotic chemical selectivity. In this study, we used deep sequencing to investigate the partitioning of randomized RNA overhangs into ligated products by either splinted ligation or loop-closing ligation. Comprehensive sequence-reactivity profiles revealed that loop-closing ligation preferentially yields hairpin structures with loop sequences UNNG, CNNG, and GNNA (where N represents A, C, G, or U) under competing conditions.
View Article and Find Full Text PDFArch Gynecol Obstet
December 2024
Department of Obstetrics, Sichuan Jinxin Xinan Women and Children Hospital, Chengdu, Sichuan, China.
Introduction: Considering the effective treatment of postpartum hemorrhage, intrauterine balloon tamponed can apply pressure from the inside of the uterus, and uterine compression suture can apply pressure from the outside of the uterus. Although combining the two methods can enhance the effectiveness of hemostasis, there is a paucity of studies reporting on outcome. The aim of this study was to report a surgical protocol for postpartum hemorrhage by intrauterine balloon tamponing combined with mid-section loop ligation and its subsequent effects on the uterus.
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