This pilot study explored the use of tensiometry as a measure of retention of knot tying skills. Medical students learned a one-handed square knot tying technique. Their final performances were video recorded and these videos were uploaded on to a website. Students were divided into two groups: an observational learning group that had access to videos before a retention test, and a control group that did not. After a two-week retention period, all students came back and performed one more trial to test the amount of retention of the skill. Tensiometry was used to measure strengths of the knots before and after the retention period. The scores showed no significant difference between the groups (p>0.308) or tests (p>0.737). We interpret the results to suggest that tensiometry is not sensitive enough to detect degradation in the performance of fundamental clinical skills as they are forgotten after being taught.
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Nat Commun
December 2024
Department of Atmospheric and Oceanic Sciences, McGill University, Montréal, QC, Canada.
Accurate surface tension measurements are key to understanding and predicting the behavior of atmospheric aerosols, particularly their formation, growth, and phase transitions. In Earth's atmosphere, aerosols often exist in metastable states, such as being supercooled or supersaturated. Standard tensiometry instruments face challenges in accessing these states due to the large sample volumes they require and rapid phase changes near surfaces.
View Article and Find Full Text PDFBioorg Chem
December 2024
Departamento de Química, Universidade Federal de São Paulo, Diadema, SP, Brazil. Electronic address:
A natural product isolated from Brazilian plant species Baccharis retusa (Asteraceae), 15β-senecioyloxi-ent-kaurenoic acid (1), demonstrated activity against trypomastigotes of the parasite Trypanosoma cruzi but it was inactive against intracellular forms. In the present work, compound 1a, a methyl ester derivative of 1, exhibited activity against intracellular amastigotes (EC = 11.8 μM), similar to that determined by the standard drug benznidazol (EC = 16.
View Article and Find Full Text PDFLangmuir
November 2024
Chemical and Biomolecular Engineering Department, University of California, Berkeley, Berkeley, California 94760, United States.
Particle-laden interfaces stabilize emulsions and foams and can serve as a platform for multiscale materials. Favorable wetting of a particle to a fluid interface reduces the apparent interfacial tension through area replacement with a linear relationship between the apparent surface pressure and the particle area fraction. The area replacement model is widely employed, often up to particle area fraction reaching the maximum hexagonal packing.
View Article and Find Full Text PDFChem Sci
October 2024
Institute of Physical Chemistry, Center for Soft Nanoscience (SoN), University of Münster Corrensstraße 28-30 Münster 48149 Germany
Smart responsive materials have spurred the progress in high-precision drug delivery. Enormous attention has been given to characterizing drug release in bulk aqueous solutions, however, aqueous-hydrophobic interfaces are vital components of biological systems which serve as the point of entry into cells. These interfaces are involved in many key biomolecular interactions, and while the potential for drug molecules to adsorb to these interfaces is recognized, their specific role in the context of drug release remains largely unexplored.
View Article and Find Full Text PDFJ Colloid Interface Sci
February 2025
Department of Process and Life Science Engineering, Lund University, Lund, Sweden.
Hypothesis: A modified Weber number can capture the effect of emulsifier concentration and the effect of external stress in turbulent drop breakup. Moreover, the effect of emulsifiers on turbulent drop breakup cannot be adequately understood from classic slow/laminar techniques and quasi steady state interfacial tension.
Experiments: Single drop breakup visualizations are used to study the effect of polysorbate 20 on turbulent drop deformation and breakup.
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