Objectives: To compare the progression of substance use milestones between cocaine- and cannabis-dependent patients.
Methods: Using data gathered from two separate clinical studies for treatment of cocaine dependence and cannabis dependence, 130 cannabis-dependent and 112 cocaine-dependent individuals were compared on milestones related to their substance use.
Results: In cannabis- vs. cocaine-dependent patients, the mean age of first use, regular use and first treatment contact differed significantly. No statistically significant differences were found between the two groups for other measured milestones.
Conclusions: These results differ from most epidemiologic studies that suggest cocaine users progress more rapidly to regular use and treatment contact.
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http://dx.doi.org/10.1080/10550887.2011.642753 | DOI Listing |
Ann Fam Med
January 2025
Department of Family Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Purpose: Offering medication for opioid use disorder (MOUD) in primary care can increase access to effective opioid use disorder treatment and help address the US opioid crisis. We describe a primary care office-based opioid treatment program and addiction consultation service model designed to support small, rural clinics to increase their capacity for MOUD.
Methods: This is an evaluation of an intervention to increase clinic capacity to offer MOUD.
Ther Innov Regul Sci
December 2024
University of Witwatersrand, 7 York road, Parktown, Johannesburg, 2017, South Africa.
Purpose: This study aimed to assess the current regulatory review process of the Zambia Medicines Regulatory Authority (ZAMRA) by identifying the key milestones and target timelines achieved for products approved from 2020 to 2023, as well as good review and quality decision-making practices implemented in the review process.
Methods: A standardised, validated questionnaire; Optimising Efficiencies in Regulatory Agencies (OpERA) and the OpERA Data Collection Template were completed by the author.
Results: Three review models are used by ZAMRA to review new active substances (NASs) and generic products: verification, for products prequalified by the World Health Organization or approved by a stringent regulatory authority (SRA); abridged, for well-established molecules or SRA-approved products; or full, for products not otherwise prequalified.
J Biomol Struct Dyn
December 2024
CMML-Catalysis and Molecular Modelling Lab, Department of Chemical Sciences, Tezpur University, Sonitpur, Assam, India.
The scientific community has achieved a remarkable milestone by creating efficacious vaccines against the SARS-CoV-2 virus. The treatment alternatives are still restricted, though. The bioactive ingredients present in natural plants are known to exhibit diverse pharmacological effects against many diseases.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
December 2024
Department of Environmental Science, College of Agriculture and Environmental Sciences, University of South Africa, Christiaan de Wet Road, Florida, Johannesburg, 1709, South Africa.
Per- or poly-fluoroalkyl substances (PFAS) are a group of anthropogenic compounds that are used in a variety of industrial processes and consumer products with their ubiquitous presence in the environment recently gaining relevant attention. Progress and milestones on PFAS contamination within multiple environments from African continent are highlighted in this review. Identification and quantitation of PFAS within African environments is important to the public at large because of their toxicity and possible ecotoxicological risk.
View Article and Find Full Text PDFAlcohol Clin Exp Res (Hoboken)
December 2024
The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Camperdown, New South Wales, Australia.
Background: Prior research has shown that early alcohol experiences, such as age of initiation and speed of progression between drinking milestones, vary across racial/ethnic groups. To inform culturally tailored prevention efforts, this longitudinal study examined racial/ethnic differences in the associations of drinking firsts at home and with parental knowledge with alcohol use outcomes among underage youth.
Methods: The study included baseline and five follow-up surveys, collected every 6 months, from California adolescents (ages 12-16 years at baseline).
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