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Synergistic interactions between kainate and mGlu receptors regulate bouton Ca signalling and mossy fibre LTP. | LitMetric

Synergistic interactions between kainate and mGlu receptors regulate bouton Ca signalling and mossy fibre LTP.

Sci Rep

MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, Bristol, BS8 1TD, United Kingdom.

Published: August 2013

AI Article Synopsis

Article Abstract

It is currently unknown why glutamatergic presynaptic terminals express multiple types of glutamate receptors. We have addressed this question by studying both acute and long-term regulation of mossy fibre function in the hippocampus. We find that inhibition of both mGlu₁ and mGlu₅ receptors together can block the induction of mossy fibre LTP. Furthermore, mossy fibre LTP can be induced by the pharmacological activation of either mGlu₁ or mGlu₅ receptors, provided that kainate receptors are also stimulated. Like conventional mossy fibre LTP, chemically-induced mossy fibre LTP (chem-LTPm) depends on Ca²⁺ release from intracellular stores and the activation of PKA. Similar synergistic interactions between mGlu receptors and kainate receptors were observed at the level of Ca²⁺ signalling in individual giant mossy fibre boutons. Thus three distinct glutamate receptors interact, in both an AND and OR gate fashion, to regulate both immediate and long-term presynaptic function in the brain.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216588PMC
http://dx.doi.org/10.1038/srep00103DOI Listing

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