AI Article Synopsis
- De novo malignancies are a growing issue for transplant patients as their survival rates improve, with EBV-associated B-cell lymphoma being the most common in children post-transplant.
- Current treatments for post-transplant lymphoproliferative disorder (PTLD) include pharmacologic, biologic, and cell-based therapies, but their effectiveness varies, indicating a need for new options.
- The article reviews these treatments and explores the life cycle of the Epstein-Barr Virus (EBV), focusing on how EBV-related proteins LMP1 and LMP2a may influence the development of B-cell lymphomas to identify potential new treatments.
Article Abstract
De novo malignancies represent an increasing concern in the transplant population, particularly as long-term graft and patient survival improves. EBV-associated B-cell lymphoma in the setting of PTLD is the leading malignancy in children following solid organ transplantation. Therapeutic strategies can be categorized as pharmacologic, biologic, and cell-based but the variable efficacy of these approaches and the complexity of PTLD suggest that new treatment options are warranted. Here, we review current therapeutic strategies for treatment of PTLD. We also describe the life cycle of EBV, addressing the viral mechanisms that contribute to the genesis and persistence of EBV+ B-cell lymphomas. Specifically, we focus on the oncogenic signaling pathways activated by the EBV LMP1 and LMP2a to understand the underlying mechanisms and mediators of lymphomagenesis with the goal of identifying novel, rational therapeutic targets for the treatment of EBV-associated malignancies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052840 | PMC |
| http://dx.doi.org/10.1111/j.1399-3046.2012.01656.x | DOI Listing |
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