AI Article Synopsis
- Palladium(II) catalyst enables a new oxidative cyclization process for alkenes using tert-butanesulfinamides, leading to the creation of enantiopure 2,5-disubstituted pyrrolidines.
- The method utilizes easily accessible and modifiable starting materials, making it practical for synthetic applications.
- This is the first documented instance of metal-catalyzed addition of sulfinamide nucleophiles to alkenes, showcasing a novel approach in organic chemistry.
Article Abstract
Palladium(II)-catalyzed aerobic oxidative cyclization of alkenes with tethered tert-butanesulfinamides furnishes enantiopure 2,5-disubstituted pyrrolidines, originating from readily available and easily diversified starting materials. These reactions are the first reported examples of metal-catalyzed addition of sulfinamide nucleophiles to alkenes.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298084 | PMC |
| http://dx.doi.org/10.1021/ol3000519 | DOI Listing |
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