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http://dx.doi.org/10.1001/archdermatol.2011.1406 | DOI Listing |
Pharmaceutics
December 2024
Phase I Clinical Trial Unit, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
Background: A broad-spectrum anti-SARS-CoV-2 monoclonal antibody (mAb), SA55, is highly effective against SARS-CoV-2 variants. This trial aimed at demonstrating the safety, tolerability, local drug retention and neutralizing activity, systemic exposure level, and immunogenicity of the SA55 nasal spray in healthy individuals.
Methods: This phase I, dose-escalation clinical trial combined an open-label design with a randomized, controlled, double-blind design.
Nutrients
January 2025
School of Sport Science, Beijing Sport University, Beijing 100084, China.
Background: Both listening to music during warm-up and consuming caffeine before exercise have been independently shown to enhance athletic performance. However, the potential synergistic effects of combining these strategies remain largely unexplored. To date, only two studies have reported additional benefits to combining music during warm-up with a caffeine dose of 3 mg/kg on taekwondo-specific performance tasks.
View Article and Find Full Text PDFNutrients
January 2025
College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471000, China.
Background/objectives: With the improvement of living standards, alcoholic liver disease caused by long-term drinking has been a common multiple disease. Probiotic interventions may help mitigate liver damage caused by alcohol intake, but the mechanisms need more investigation.
Methods: This study involved 70 long-term alcohol drinkers (18-65 years old, alcohol consumption ≥20 g/day, lasting for more than one year) who were randomly assigned to either the BC99 group or the placebo group.
Nutrients
January 2025
Graduate School of Bioscience and Biotechnology, Chubu University, 1200, Matsumoto-cho, Kasugai-city 487-8501, Aichi, Japan.
Background/objectives: Facial bone density, including the jawbone, declines earlier than that of the lumbar spine and calcaneus. Calcium maltobionate is reported to mitigate bone resorption and maintain bone density of the lumbar spine in post-menopausal women, but its effects on facial bone density remain understudied. Therefore, this study compared variations in facial bone mineral density with variations in calcaneal bone mineral density and bone resorption markers among healthy women, examining differences between pre- and post-menopause and the effects of continuous calcium maltobionate intake.
View Article and Find Full Text PDFNutrients
January 2025
Performance and Sport Rehabilitation Laboratory, University of Castilla La Mancha, 45071 Toledo, Spain.
Background: This study aimed to analyze the effect of caffeine ingestion on basketball performance in semi-professional female players.
Methods: A double-blind, placebo-controlled, randomized experimental design was conducted, in two different periods separated by a week. Twelve female basketball players ingested 3 mg of caffeine/kg of body mass or a placebo.
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