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Heterogeneity in response to neoadjuvant radiotherapy between soft tissue sarcoma histotypes: associations between radiology and pathology findings.
Eur Radiol
December 2024
Department of Radiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Objective: To investigate imaging biomarkers of tumour response by describing changes in imaging and pathology findings after neoadjuvant radiotherapy (nRT) and exploring their correlations.
Materials And Methods: Tumour diameter, volume, and tumour-to-muscle signal intensity (SI) ratio were collected before and after radiotherapy in a cohort of 107 patients with intermediate/high-grade STS and were correlated with post-radiotherapy pathology findings (percentage of necrosis, viable cells, and fibrosis) using Spearman Rank test. Pathological complete response (pCR) was defined as no residual viable cells present, whereas the presence of < 10% viable cells was defined as near-complete pathologic response (near-pCR).
Liposarcomas are the most common soft tissue sarcoma primarily originating in deep soft tissues and the retroperitoneum. Sarcoma classification includes atypical lipomatous tumor/well-differentiated liposarcoma (WDL) and dedifferentiated liposarcoma (DDL), myxoid liposarcoma, and pleomorphic liposarcoma. DDL is most prevalent in the retroperitoneum and often has two distinct components, a well-differentiated lipomatous component and a dedifferentiated nonlipomatous component that could be morphologically similar to malignant fibrous histiocytoma (MFH) or fibrosarcoma.
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Cureus
November 2024
Radiation Oncology, Shimane University Faculty of Medicine, Izumo, JPN.
Malignant psoas syndrome is caused by a malignant tumor infiltrating the psoas muscle and is characterized by severe pain. Currently, no definitive diagnostic or therapeutic approaches have been established for this condition. Although multiple medications are often used for pain relief, pain management can often be challenging, and there are various treatment options.
View Article and Find Full Text PDFA Very late intracardiac myxoid liposarcoma metastasis.
Eur Heart J Cardiovasc Imaging
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Department of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Lugano, Switzerland.
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