AI Article Synopsis
- The study focuses on the bulk production of calcium carbonate nanotubes (CCNTs) which serve as hollow structural particles (HSPs) that are biocompatible and have a large surface area for applications in drug delivery and biosensing.
- Characterization techniques confirm that CCNTs have a stable tube-like structure that effectively promotes the diffusion of the drug podophyllotoxin (PPT), achieving high drug loading and encapsulation efficiency.
- In vitro tests reveal that PPT-loaded CCNTs are less toxic to healthy cells while exhibiting enhanced antitumor effects and improved apoptosis in cancer cells, presenting a promising new nanomaterial for targeted drug delivery.
Article Abstract
Bulk fabrication of ordered hollow structural particles (HSPs) with large surface area and high biocompatibility simultaneously is critical for the practical application of HSPs in biosensing and drug delivery. In this article, we describe a smart approach for batch synthesis of calcium carbonate nanotubes (CCNTs) based on supported liquid membrane (SLM) with large surface area, excellent structural stability, prominent biocompatibility, and acid degradability. The products were characterized by transmission electron micrograph, X-ray diffraction, Fourier transform infrared spectra, UV-vis spectroscopy, zeta potential, and particle size distribution. The results showed that the tube-like structure facilitated podophyllotoxin (PPT) diffusion into the cavity of hollow structure, and the drug loading and encapsulation efficiency of CCNTs for PPT are as high as 38.5 and 64.4 wt.%, respectively. In vitro drug release study showed that PPT was released from the CCNTs in a pH-controlled and time-dependent manner. The treatment of HEK 293T and SGC 7901 cells demonstrated that PPT-loaded CCNTs were less toxic to normal cells and more effective in antitumor potency compared with free drugs. In addition, PPT-loaded CCNTs also enhanced the apoptotic process on tumor cells compared with the free drugs. This study not only provides a new kind of biocompatible and pH-sensitive nanomaterial as the feasible drug container and carrier but more importantly establishes a facile approach to synthesize novel hollow structural particles on a large scale based on SLM technology.
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| http://dx.doi.org/10.1007/s12011-012-9325-9 | DOI Listing |
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