AI Article Synopsis
- The study investigates whether offspring of long-lived families exhibit lower activity in the HPA axis, indicated by cortisol levels, compared to their partners.
- Offspring showed significantly lower salivary cortisol levels in both morning and evening measurements compared to partners, suggesting reduced HPA activity.
- No significant difference in cortisol feedback sensitivity was observed between offspring and partners, indicating that while cortisol secretion is lower, feedback mechanisms are similar.
Article Abstract
Background: Reported findings are inconsistent whether hypothalamic-pituitary-adrenal (HPA) signaling becomes hyperactive with increasing age, resulting in increasing levels of cortisol. Our previous research strongly suggests that offspring from long-lived families are biologically younger. In this study we assessed whether these offspring have a lower HPA axis activity, as measured by lower levels of cortisol and higher cortisol feedback sensitivity.
Methods: Salivary cortisol levels were measured at four time points within the first hour upon awakening and at two time points in the evening in a cohort comprising 149 offspring and 154 partners from the Leiden Longevity Study. A dexamethasone suppression test was performed as a measure of cortisol feedback sensitivity. Age, gender and body mass index, smoking and disease history (type 2 diabetes and hypertension) were considered as possible confounding factors.
Results: Salivary cortisol secretion was lower in offspring compared to partners in the morning (Area Under the Curve = 15.6 versus 17.1 nmol/L, respectively; p = 0.048) and in the evening (Area Under the Curve = 3.32 versus 3.82 nmol/L, respectively; p = 0.024). Salivary cortisol levels were not different after dexamethasone (0.5 mg) suppression between offspring and partners (4.82 versus 5.26 nmol/L, respectively; p = 0.28).
Conclusion: Offspring of nonagenarian siblings are marked by a lower HPA axis activity (reflected by lower diurnal salivary cortisol levels), but not by a difference in cortisol feedback sensitivity. Further in-depth studies aimed at characterizing the HPA axis in offspring and partners are needed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278433 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031166 | PLOS |
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