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Clinical and cost-effectiveness of parenting intervention for mothers experiencing psychosocial stress: insights from the early closure of the Mellow Babies RCT.
Public Health Res (Southampt)
December 2024
Edinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, UK.
Background: Problems in children's early social and emotional development are likely to have major long-term consequences for the individual and society: maternal emotional well-being is associated with better outcomes. Interventions designed to improve both maternal mental health and the mother-child relationship are thus likely to benefit both maternal health and child development.
Objectives: To establish the clinical and cost-effectiveness of the Mellow Babies parenting intervention for women experiencing psychosocial stress and their 6- to 18-month-old babies.
Accelerating evidence generation: Addressing critical challenges and charting a path forward.
J Clin Transl Sci
October 2024
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Efficient evidence generation to assess the clinical and economic impact of medical therapies is critical amid rising healthcare costs and aging populations. However, drug development and clinical trials remain far too expensive and inefficient for all stakeholders. On October 25-26, 2023, the Duke Clinical Research Institute brought together leaders from academia, industry, government agencies, patient advocacy, and nonprofit organizations to explore how different entities and influencers in drug development and healthcare can realign incentive structures to efficiently accelerate evidence generation that addresses the highest public health needs.
View Article and Find Full Text PDFArticle Synopsis
- * A scoping review will investigate current stakeholder engagement practices in NCD IR within LMICs by utilizing a systematic screening process and thematic synthesis, focusing on studies published from 2011 onward.
- * Ethical considerations are emphasized, including respect for original authors and data integrity, with plans for dissemination through various channels like peer-reviewed journals, conferences, and social media to share findings effectively.
Anticholinergic Exposure, Drug Dose and Postoperative Delirium: Comparison of Dose-Related and Non-Dose-Related Anticholinergic Burden Scores in a Retrospective Cohort Study of Older Orthopaedic and Trauma Surgery Patients.
Drugs Aging
December 2024
Hospital Pharmacy, LMU University Hospital, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany.
Purpose: Postoperative delirium (POD) is a common complication in older adult patients after surgery. A patient's preoperative anticholinergic (AC) burden is a potentially modifiable risk factor for POD. As the influence of the drug dose remains unknown, we aimed to compare three AC burden scores in relation to POD, two of which were dose-related.
View Article and Find Full Text PDFPatient characteristics and health system encounters of decedents not marked deceased in the electronic health record.
JAMIA Open
December 2024
UCLA Division of General Internal Medicine and Health Services Research, University of California, Los Angeles, CA 90024, United States.
Objectives: Health systems are increasingly accountable for patients and require accurate electronic health record (EHR) vital status. We recently demonstrated that 19% of seriously ill primary care patients in one system were not marked dead in the EHR and 80% of these decedents had an encounter or appointment outstanding after death. Herein we describe the mechanism of identifying decedents whose death is not captured at the level of the EHR, characterize these decedents, and describe medications refilled after death.
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