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Body mass index affects imatinib exposure: Real-world evidence from TDM with adaptive dosing.
Fundam Clin Pharmacol
February 2025
PRISM Biogénopôle La Timone University Hospital of Marseille, APHM, Marseille, France.
Background: Imatinib is the treatment of elderly or frail patients with chronic myeloid leukemia (CML). Trough levels of around 1000 ng/ml are considered as the target exposure.
Objectives: We searched for baseline parameters associated with imatinib pharmacokinetics, and studied the clinical impact of subsequent adaptive dosing.
Carboxylated nanocellulose from quinoa husk for enhanced protease immobilization and stability of protease in biotechnological applications.
Sci Rep
January 2025
Department of Nanotechnology, Agricultural Biotechnology Research Institute of Iran (ABRII), Agricultural Research Education and Extension Organization (AREEO), P. O. Box: 31535-1897, Karaj, Iran.
Herein, an efficient and feasible approach was developed to oxidize low-cost agricultural waste (quinoa husk, QS) for the synthesis of carboxylated nanocellulose (CNC). The as-prepared rod-like CNCs (average diameter of 10 nm and length of 103 nm) with a high specific surface area (173 m/g) were utilized for the immobilization of a model protease enzyme (PersiProtease1) either physically or via covalent attachment. For chemical immobilization, CNCs were firstly functionalized with N, N'-dicyclohexylcarbodiimide (DCC) to provide DCNCs nanocarrier which could covalently bond to enzyme trough nucleophilic substitution reaction and formation of the amide bond between DCNCs and enzyme.
View Article and Find Full Text PDFHydrological dynamics of the Yangtze river-Dongting lake system after the construction of the three Gorges dam.
Sci Rep
January 2025
School of Ocean Engineering and Technology/Institute of Estuarine and Coastal Research, Sun Yat-sen University, Guangzhou, 510275, China.
The Yangtze River-Dongting Lake link has gotten a lot of attention as a because of the Three Gorges Project. However, the hydrological dynamic process and future direction of the river-lake interaction in the context of sediment reduction are yet unknown. Based on Dongting Lake Basin runoff and sediment data from 1961 to 2020, as well as field monitoring data of turbidity and flow velocity from Yichang to Chenglingji section of the Yangtze River, this paper examines the runoff and sediment variation law and hydrological dynamic process of Chenglingji, the only outlet connecting Dongting Lake to the Yangtze River, and reveals the development trend of the river-lake relationship.
View Article and Find Full Text PDFHELP-KIDNEY: Health Literacy and Patient Outcomes in Pediatric Kidney Transplant.
Pediatr Transplant
February 2025
Director, Multi-Organ Transplant Program, Associate Professor of Pediatrics, University of British Columbia and BC Children's Hospital, Vancouver, Canada.
Background: Below adequate health literacy is common and linked to increased risk of adverse health outcomes. Supporting optimal health following kidney transplantation requires the capacity to understand health information and make decisions about care. The impact of low health literacy in the context of pediatric kidney transplant has not previously been studied.
View Article and Find Full Text PDFAmoxicillin Blood Concentration in High-Dose Intravenous Discontinuous Amoxicillin: Look Beyond Numbers. Max-Amox Study.
Clin Ther
December 2024
Department of Infectious Diseases, CHU Clermont-Ferrand, Clermont-Ferrand, France. Electronic address:
Purpose: High doses of amoxicillin are recommended to treat severe infections such as endocarditis. Amoxicillin causes dose-dependent toxicities, in particular crystal nephropathy. Toxicity could be avoided by monitoring of amoxicillin trough plasma concentrations (ATPC).
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