A selenium analogue of amino-D-luciferin, aminoseleno-D-luciferin, is synthesized and shown to be a competent substrate for the firefly luciferase enzyme. It has a red-shifted bioluminescence emission maximum at 600 nm and is suitable for bioluminescence imaging studies in living subjects.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494413PMC
http://dx.doi.org/10.1002/anie.201105653DOI Listing

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