AI Article Synopsis
- Brown adipose tissue (BAT) is key for burning calories through thermogenesis in mammals, helping to prevent weight gain by reducing the storage of fat in white adipose tissue (WAT).
- This study showcases a method to effectively measure BAT volume and metabolic function in live rats using a 9.4T MRI scanner, in contrast to traditional PET-CT scans that measure BAT activity.
- The findings confirm that MRI can reliably assess BAT volume in vivo, correlating well with direct measurements from tissue samples, and successfully map metabolic changes in BAT related to pharmacological stimulation.
Article Abstract
Brown adipose tissue (BAT) is the primary tissue responsible for nonshivering thermogenesis in mammals. The amount of BAT and its level of activation help regulate the utilization of excessive calories for thermogenesis as opposed to storage in white adipose tissue (WAT) which would lead to weight gain. Over the past several years, BAT activity in vivo has been primarily assessed by positron emission tomography-computed tomography (PET-CT) scan using 2-[18F]-fluoro-2-deoxy-D-glucose (18F-FDG) to measure glucose utilization associated with BAT mitochondrial respiration. In this study, we demonstrate the feasibility of mapping and estimating BAT volume and metabolic function in vivo in rats at a 9.4T magnetic resonance imaging (MRI) scanner using sequences available from clinical MR scanners. Based on the morphological characteristics of BAT, we measured the volume distribution of BAT with MRI sequences that have strong fat-water contrast. We also investigated BAT volume by utilizing spin-echo MRI sequences. The in vivo MRI-estimated BAT volumes were correlated with direct measurement of BAT mass from dissected samples. Using MRI, we also were able to map hemodynamic responses to changes in BAT metabolism induced pharmacologically by β3-adrenergic receptor agonist, CL-316,243 and compare this to BAT activity in response to CL-316,243 assessed by PET 18F-FDG. In conclusion, we demonstrate the feasibility of measuring BAT volume and function in vivo using routine MRI sequences. The MRI measurement of BAT volume is consistent with quantitative measurement of the tissue ex vivo.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383098 | PMC |
| http://dx.doi.org/10.1038/oby.2012.22 | DOI Listing |
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