Objective: Endoscopic methods to perform intracardiac procedures are of enormous interest, with the introduction of transcatheter techniques for complex cardiac procedures. In the present study, we demonstrate the use of a novel transapical cardioscopy system to visualize intracardiac structures in a porcine model.
Methods: The cardioscope was designed to mount a miniature CCD camera at its tip and was covered in a blunt convex Plexiglass top that allowed displacement and visualization of the tissue in front of the cardioscope. Transapical access for 11-mm cardioscopy was performed by way of a median sternotomy (n = 4) and minithoracotomy (n = 1) in an anesthetized porcine model, and various cardiac structures were imaged under beating heart conditions. The images from the camera were projected onto a monitor for the operator to guide cardioscope positioning.
Results: Video images and identification of structures on the left side of an in vivo beating porcine heart were obtained. Initially, the papillary muscle and mitral valve components were evaluated. The left atrium was entered, and the pulmonary vein orifices and atrial appendage were confirmed. Next, the camera was positioned within the left ventricle, and the ventricular portion of the trileaflet aortic valve was inspected. Using direct visualization, the camera was passed into the proximal ascending aorta. The left and right coronary arteries were also visualized. A catheter was introduced by way of a side port to confirm the position of the aortic valve leaflets during visualization. The pig experienced no significant decrease in blood pressure and maintained a stable heart rate throughout the procedure. The port was removed, and the transapical incision was closed with minimal blood loss during the procedure and closure of the orifice.
Conclusions: Transapical cardioscopy is a novel approach that allows for precise visualization of intracardiac structures within a beating porcine heart without the use of cardiopulmonary bypass. This technique might allow for more successful minimally invasive valvular, intracardiac, or ascending aortic procedures without the use of radiation.
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http://dx.doi.org/10.1016/j.jtcvs.2011.11.038 | DOI Listing |
BMJ Open
December 2024
Department of Medicine, MacKay Medical College, New Taipei, Taiwan
Objective: Heart rate serves as a critical prognostic factor in heart failure (HF) patients. We hypothesise that elevated heart rate in critically ill HF patients on discharge from the intensive care unit (ICU) could be linked to adverse outcomes.
Design: A single-centre retrospective cohort study.
Cardiovasc Eng Technol
December 2024
Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Purpose: Advancements in minimally invasive technologies to decrease postoperative morbidity and recovery times represent a large opportunity for mitral valve repair operations. However, current technologies are unable to replicate gold standard surgical neochord implantation.
Methods: We developed a novel neochordal repair device, Minimally Invasive Ventricular Anchoring Neochordoplasty (MIVAN), which operates via transcatheter, trans-septal anchoring to the posterior ventricular wall.
J Voice
December 2024
Department of Otolaryngology Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address:
Objectives: Suspension laryngoscopy can trigger vagal reflexes, leading to a decrease in heart rate, a phenomenon that is more common in patients with a high body mass index (BMI). This study aims to systematically evaluate the effect of BMI on heart rate during suspension laryngoscopy (SL-HR) in patients with laryngeal lesions.
Methods: We employed univariate generalized linear regression and stratified analyses to assess the relationship between BMI and changes in SLHR, adjusting for confounders such as age, gender, intubation type, and depth.
Respir Med
December 2024
University of California, Division of Pulmonary, Critical Care, Sleep Medicine and Physiology, 9300 Campus Point Drive, MC #7381, La Jolla, San Diego, CA 92037. Electronic address:
Unlabelled: Exercise-induced pulmonary arterial hypertension (EiPH) is often treated with off-label use of pulmonary arterial hypertension-targeted therapy (PH-targeted therapy). Most measures of PAH severity are normal in patients with EiPH, posing challenges in evaluating for physiological improvement in patients treated for EiPH. In this study, we used non-invasive cardiopulmonary exercise testing (CPET) to assess for objective improvement in patients treated for EiPH.
View Article and Find Full Text PDFPLoS One
December 2024
Division of Pharmacology, National Institute of Health Sciences, Kawasaki, Kanagawa, Japan.
Cardiotoxicity associated with hepatic metabolism and drug-drug interactions is a serious concern. Predicting drug toxicity using animals remains challenging due to species and ethical concerns, necessitating the need to develop alternative approaches. Drug cardiotoxicity associated with hepatic metabolism cannot be detected using a cardiomyocyte-only evaluation system.
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