Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jss.2011.12.001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Coagulofibrinolytic effects of recombinant soluble thrombomodulin in prolonged porcine cardiac arrest.
Resusc Plus
December 2023
Departments of Emergency Medicine, University of Michigan, United States.
Aim: To evaluate coagulofibrinolytic abnormalities and the effects of ART-123 (recombinant human thrombomodulin alpha) in a porcine model of cardiac arrest and prolonged cardiopulmonary resuscitation (CA/CPR).
Methods: Fifteen pigs ( = 5 per group) underwent 8 minutes of no-flow CA followed by 50 minutes of mechanical CPR, while 2 pigs underwent sham arrest. CA/CPR animals were randomized to receive saline or 1 mg/kg ART-123 pre-arrest (5 minutes prior to ventricular fibrillation) or post-arrest (2 minutes after initiation of CPR).
Integrin α10β1-selected mesenchymal stem cells reduced hypercoagulopathy in a porcine model of acute respiratory distress syndrome.
Respir Res
May 2023
Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden.
Mesenchymal stem cells (MSCs) have been studied for their potential benefits in treating acute respiratory distress syndrome (ARDS) and have reported mild effects when trialed within human clinical trials. MSCs have been investigated in preclinical models with efficacy when administered at the time of lung injury. Human integrin α10β1-selected adipose tissue-derived MSCs (integrin α10β1-MSCs) have shown immunomodulatory and regenerative effects in various disease models.
View Article and Find Full Text PDFHemorrhagic shock and tissue injury provoke distinct components of trauma-induced coagulopathy in a swine model.
Eur J Trauma Emerg Surg
April 2023
Department of Health Systems, Management and Policy, School of Public Health, University of Colorado Denver, Aurora, CO, USA.
Introduction: Tissue injury (TI) and hemorrhagic shock (HS) are the major contributors to trauma-induced coagulopathy (TIC). However, the individual contributions of these insults are difficult to discern clinically because they typically coexist. TI has been reported to release procoagulants, while HS has been associated with bleeding.
View Article and Find Full Text PDFA natural history study of coagulopathy in a porcine 40% total body surface area burn model reveals the time-dependent significance of functional assays.
Burns
December 2022
United States Army Institute of Surgical Research, JBSA Fort Sam, Houston, TX 78234, USA; Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. Electronic address:
Various studies have reported discordant results on the magnitude and direction of burn-induced coagulopathy (BIC), which has recently been associated with multiple organ dysfunction syndrome (MODS) and death. The increased mechanistic understanding of BIC is due, in part, to novel assays that have expanded the armamentarium beyond traditional tests like PT and aPTT. Still, BIC is a dynamic process, and the progression is difficult to define in the thermally-injured.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!