In vivo physiological saline-infused hepatic vessel imaging using a two-crystal-interferometer-based phase-contrast X-ray technique.

J Synchrotron Radiat

Allied Health Sciences and Graduate School of Medical Science, Kitasato University, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0373, Japan.

Published: March 2012

AI Article Synopsis

  • A two-crystal-interferometer phase-contrast X-ray imaging system was used to image the portal vein, capillaries, and hepatic vein in live rats by injecting physiological saline.
  • The technique successfully visualized vessels larger than 0.06 mm in diameter with a low radiation dose of 552 µGy.
  • This method offers a potential alternative to conventional angiography, eliminating the need for iodine contrast agents and their associated side effects.

Article Abstract

Using a two-crystal-interferometer-based phase-contrast X-ray imaging system, the portal vein, capillary vessel area and hepatic vein of live rats were revealed sequentially by injecting physiological saline via the portal vein. Vessels greater than 0.06 mm in diameter were clearly shown with low levels of X-rays (552 µGy). This suggests that in vivo vessel imaging of small animals can be performed as conventional angiography without the side effects of the presently used iodine contrast agents.

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Source
http://dx.doi.org/10.1107/S0909049511056226DOI Listing

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