AI Article Synopsis
- The study examined the clinical and laboratory characteristics of 11 acute myeloid leukemia (AML) patients with a specific chromosomal translocation (t(7;11)(p15;p15)).
- Eight patients were female with varying subtypes of AML, and specific cell markers were expressed widely among them.
- The findings indicate that the t(7;11)(p15;p15) translocation is rare in AML and is associated with poor prognosis, including symptoms like anemia and thrombocytopenia.
Article Abstract
Objective: To investigate clinical and laboratory characteristics of acute myeloid leukemia (AML) patients with t(7;11)(p15;p15).
Methods: Eleven patients with t(7;11)(p15;p15) were retrospectively reviewed involved in cell morphology, immunophenotype, cytogenetics as well as clinical features and prognosis.
Results: Eight patients out of the eleven were female, six patients were AML-M2a, two M4, two M5, and one M6. All the 11 cases expressed CD33, 10 expressed CD117 and CD13, HLA-DR and CD34 was expressed in 7 and 6 patients, respectively. Karyotypes of all the patients were t(7;11) (p115;p15), additional trisomy 8 were found in only one patient. FLT3-ITD was positive in one of nine patients who were analysed for FLT3-ITD and FLT3-TKD. Two patients were alive, and one lost to followed up, while the rest of eight were dead.
Conclusion: The t(7;11) (p15;p15) abnormalities is one of rare chromosomal translocation in patients with AML. AML patients with t(7;11) (p15;p15) have clinical features of anemia, thrombocytopenia, higher white blood cell, and poor prognosis.
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