Activation-induced cytidine deaminase (AID) is essential for class switch recombination and somatic hypermutation. Its deregulated expression acts as a genomic mutator that can contribute to the development of various malignancies. During treatment with imatinib mesylate (IM), patients with chronic myeloid leukemia often develop hypogammaglobulinemia, the mechanism of which has not yet been clarified. Here, we provide evidence that class switch recombination on B-cell activation is apparently inhibited by IM through down-regulation of AID. Furthermore, expression of E2A, a key transcription factor for AID induction, was markedly suppressed by IM. These results elucidate not only the underlying mechanism of IM-induced hypogammaglobulinemia but also its potential efficacy as an AID suppressor.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1182/blood-2011-01-327932 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Persistence After Switching From Adalimumab Biosimilar MSB11022 to Adalimumab Biosimilar GP2017 in Patients With Chronic Inflammatory Rheumatic Diseases.
J Pharm Technol
December 2024
Rheumatology Department, Hospital de Sagunto, Port de Sagunt, Spain.
Provide real-world data on switching from adalimumab biosimilar MSB11022 to GP2017 related to persistence, adherence, and safety in adult patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and axial spondyloarthritis (axSpA). Retrospective cohort study that used registries and medical records from a single hospital (June 2022 to April 2024). Adult patients with RA, PsA, and axSpA treated with adalimumab biosimilar MSB11022 who switched to biosimilar GP2017 were identified and followed up until April 2024, or disenrollment.
View Article and Find Full Text PDFOrganic Iono-Optoelectronics: From Electrochromics to Artificial Retina.
Acc Chem Res
December 2024
Tarpo Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
ConspectusOrganic mixed ionic electronic conductors (OMIECs) represent an exciting and emerging class of materials that have recently revitalized the field of organic semiconductors. OMIECs are particularly attractive because they allow both ionic and electronic transport while retaining the inherent benefits of organic semiconducting materials such as mechanical conformability and biocompatibility. These combined properties make the OMIECs ideal for applications in bioelectronics, energy storage, neuromorphic computing, and electrochemical transistors for sensing.
View Article and Find Full Text PDFMedical education, which generally relied heavily on intelligence quotients, has found a new value in emotional intelligence (EI), specifically after the challenges faced during the COVID-19 pandemic. The COVID-19 pandemic has had some apparent and some intangible effects, as this required an emergency switch to online teaching and learning. Aim: This study was conducted to compare the trait emotional intelligence (TEI) score of medical undergraduates with the increasing number of years of medical curriculum.
View Article and Find Full Text PDFHerein, we present a strategy to access a novel class of pH-responsive, dual-state emissive (DSE), highly fluorescent pyrrole-based chromophores diformylation of dipyrroethenes (DPE) followed by condensation with various aniline derivatives. The DPE-based chromophores exhibit a large Stokes shift and maintain good fluorescence quantum yields. Remarkably, these chromophores demonstrate reversible colourimetric changes and a fluorometric 'on-off-on' switch in response to pH variations.
View Article and Find Full Text PDFDo empirically-derived personality subtypes relate to cognitive inflexibility in anorexia nervosa and bulimia nervosa?
J Eat Disord
December 2024
Department of Psychiatry and Behavioral Neuroscience, University of Chicago, 5841 S. Maryland Avenue, MC 3077, Chicago, IL, 60637, USA.
Background: Accruing evidence suggests that personality-based approaches to eating disorder classification may offer several advantages over current diagnostic models, with prior research consistently identifying three personality-based groups characterized by either (1) high levels of impulsivity and dysregulation (termed the "undercontrolled" group), (2) high levels of rigidity and avoidance (termed the "overcontrolled" group), or (3) relatively normative levels of personality functioning (termed the "low psychopathology" group). Cognitive inflexibility (i.e.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!