The reaction of readily accessible 1,1-dialkylhydrazones with commercially available o-(trimethylsilyl)aryl triflates provides a direct one-step route to pharmaceutically important 1-alkylindazoles. The products are obtained in high yields by one-pot NCS-chlorination/aryne annulation or Ac(2)O-acylation/deprotection/aromatization protocols.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764999PMC
http://dx.doi.org/10.1039/c2ob07117gDOI Listing

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