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The rs1544410 and rs11568820 Variants and the Risk of Osteoporosis in the Polish Population.
Int J Mol Sci
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Department of Stem Cells and Regenerative Medicine, Institute of Natural Fibres and Medicinal Plants, Kolejowa 2, 62-064 Plewiska, Poland.
Vitamin D affects bone metabolism and calcium-phosphate metabolism. Its deficiency leads to bone mineralization disorders and is the cause of abnormal skeletal development from fetal life to the period of completed skeletal growth. In later periods of life, vitamin D deficiency leads to bone metabolism disorders, i.
View Article and Find Full Text PDFDerivation and Characterization of Isogenic Mutant and Control Human Pluripotent Stem Cell Lines.
Cells
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Jules Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Dominant optic atrophy (DOA) is the most commonly inherited optic neuropathy. The majority of DOA is caused by mutations in the gene, which encodes a dynamin-related GTPase located to the mitochondrion. OPA1 has been shown to regulate mitochondrial dynamics and promote fusion.
View Article and Find Full Text PDFThe rs1800012 polymorphism is associated with osteoporosis or fracture risk: a meta-analysis of 30 studies.
Int J Burns Trauma
December 2024
Department of Orthopedics, The Second Hospital of Hebei Medical University Shijiazhuang, Hebei, China.
Objectives: Osteoporosis is a complex disease that is influenced by several genetic markers. Many studies have examined the link between the gene rs1800012 polymorphism and osteoporosis risk. However, the findings of these studies are contradictory.
View Article and Find Full Text PDFHuman Oncostatin M deficiency underlies an inherited severe bone marrow failure syndrome.
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Laboratory of Genome Dynamics in the Immune, INSERM UMR 116, Équipe Labellisée LIGUE 2023, Paris, France.
Oncostatin M (OSM) is a cytokine with the unique ability to interact with both the OSM receptor (OSMR) and the leukemia inhibitory factor receptor (LIFR). On the other hand, OSMR interacts with IL31RA to form the interleukin-31 receptor. This intricate network of cytokines and receptors makes it difficult to understand the specific function of OSM.
View Article and Find Full Text PDFMeta-Analysis of the Association Between -2578C/A Polymorphism and Susceptibility to Type 2 Diabetic Retinopathy.
Curr Eye Res
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Fundus Disease Department, Ai'er Ophthalmology Hospital of Shangrao, Shangrao, Jiangxi, China.
Purpose: to investigate the association between vascular endothelial growth factor (-2578C/A polymorphism and susceptibility to type 2 diabetic retinopathy (T2DR) by meta-analysis.
Methods: According to the search strategy, Four databases were retrieved to identify the literature on the relationship between polymorphism and the risk of T2DR from inception to July 2024. Stata 15.
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