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Surgery for giant ovarian cysts in Guyana using single-port laparoscopy: a retrospective case series analysis.
Afr J Reprod Health
December 2024
Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, Nanjing , China.
Giant ovarian cysts (GOCs) have become less common in developed countries due to routine health screenings, but they remain prevalent in economically underdeveloped regions. Treatment options for GOCs depend on factors such as age, cyst characteristics, and pregnancy status. Minimally invasive single-port laparoscopic surgery has largely replaced traditional open surgery due to its aesthetic advantages and effectiveness.
View Article and Find Full Text PDFCobalt-Catalyzed Highly α-Stereoselective Glycosylation of Glycals.
Org Lett
December 2024
Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education and Key Laboratory of Organosilicon Material Technology of Zhejiang Province, Hangzhou Normal University, Hangzhou, 311121, P. R. China.
Following the satisfactory catalytic performance of cobalt in the -glycosylation of glycals, further study of cobalt's application values was performed under mild conditions, leading to a range of highly α-stereoselective 2,3-unsaturated , , and glycosides. The synthetic potential of the developed protocol was underscored by the late-stage functionalization of pharmaceutically relevant molecules including the canagliflozin derivative (a potential candidate for treating type 2 diabetes and alleviating pathological aging). Furthermore, control experiments were conducted to elucidate a reasonable mechanism and rule out the pathway involving the configuration conversion between and anomers.
View Article and Find Full Text PDFCorrection: F-FDG PET can effectively rule out conversion to dementia and the presence of CSF biomarker of neurodegeneration: a real-world data analysis.
Alzheimers Res Ther
November 2024
Department of Nuclear Medicine and Nancyclotep Imaging Platform, Université de Lorraine, CHRU Nancy, Nancy, F-54000, France.
Cas9/guide RNA-based gene-drive dynamics following introduction and introgression into diverse anopheline mosquito genetic backgrounds.
BMC Genomics
November 2024
Department of Microbiology & Molecular Genetics, University of California, Irvine, CA, 92697-4025, USA.
Background: Novel technologies are needed to combat anopheline vectors of malaria parasites as the reductions in worldwide disease incidence has stalled in recent years. Gene drive-based approaches utilizing Cas9/guide RNA (gRNA) systems are being developed to suppress anopheline populations or modify them by increasing their refractoriness to the parasites. These systems rely on the successful cleavage of a chromosomal DNA target site followed by homology-directed repair (HDR) in germline cells to bias inheritance of the drive system.
View Article and Find Full Text PDFFunctional Neurological Disorder in Pediatrics: Diagnostic Considerations.
R I Med J (2013)
November 2024
Article Synopsis
- Functional neurological disorder (FND) is frequently diagnosed in pediatric healthcare settings and presents with a variety of neuropsychiatric symptoms.* -
- The DSM-V marks a significant change by recognizing FND as a rule-in diagnosis rather than just a diagnosis of exclusion, focusing on specific symptom presentations.* -
- This article is the first in a six-part series that will cover diagnostic criteria, risks, and prognostic factors of FND, introducing a case study for further exploration in future articles.*
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