Objective: To analyze the prevalence and clinical characteristics of hospitalized patients with cervical cancer over the last two decades in Beijing so as to provide scientific rationales for the management of cervical cancer.
Methods: Stratified cluster sampling was employed to analyze a total of 1399 invasive cervical cancer cases from different class hospitals in Beijing during the period of 1990 - 2009.
Results: (1) The number of cervical cancer cases had been rising over the last 2 decades. (2) The age of onset ranged from 17 to 88 years old; the number of patients with stages I, II, III and IV was 772 (57.1%), 380 (28.1%), 182 (13.5%) and 18 (1.3%) respectively; 1135 (83.1%) patients were of squamous cell carcinoma while 182 (13.3%) adenocarcinoma. The last two decades was divided into 4 groups of 5 years each. The average age gradually decreased from 58.2 to 46.0 years old (P < 0.01). The proportion of patients with stages I and II also increased from 69.6% (16/23) to 89.4% (530/856); There was no significant change in histopathologic type of cervical cancer. And squamous cell carcinoma of cervix remained the predominant type (P > 0.05). (3) About 26.0% (364/1399) of cases received no vagino-recto-abdominal examination while 3.4% (48/1399) of cases were not staged.
Conclusion: Over the last two decades, the number of newly diagnosed cervical cancer cases has showed a rising trend in Beijing. And the proportions of young patients and patients with early disease have both increased. Some irregularities still exist in the diagnosis of cervical cancer. So we should pay more attention to the screening program and standardize the diagnosis, therapy and follow-up of cervical cancer.
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Am J Cancer Res
December 2024
Department of Gynecology, Gansu Provincial People's Hospital Lanzhou, Gansu, China.
Tumor-associated macrophages (TAMs) are important immune cells in the tumor micro-environment (TME) and play a key role in the occurrence and development of cervical cancer. Besides, targeting TAMs can significantly inhibit cervical cancer tumor growth, invasion, metastasis, and angiogenesis as well as affect immune regulation. This review summarizes the correlation between TAM and tumors, the mechanism of action of TAM in cervical cancer, and the potential application of TAM in the treatment of cervical cancer.
View Article and Find Full Text PDFCureus
December 2024
Infectious Disease, Tan Tock Seng Hospital, Singapore, SGP.
Nontyphoidal is a common cause of gastroenteritis but can also lead to bacteremia and extraintestinal infections, including meningitis (more frequent in children and infants), endovascular infections (e.g., endocarditis and infected aneurysms), urinary tract infections, and bone or bone marrow infections (e.
View Article and Find Full Text PDFCureus
December 2024
Obstetrics and Gynecology, Shri B M Patil Medical College Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura, IND.
Background Cervical cancer typically progresses over 10-20 years, making it a preventable disease and underscoring the importance of screening. In low-resource settings, Papanicolaou (Pap) smears and visual inspection with acetic acid (VIA) serve as primary screening tools. This study was conducted as part of the noncommunicable disease camps organized by the government of Karnataka, India.
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December 2024
Department of Obstetrics and Gynecology, Osaka Metropolitan University Graduate School of Medicine, Osaka, JPN.
Aim This study evaluates university students' knowledge and attitudes toward Human Papillomavirus (HPV) vaccination and cervical cancer screening and assesses the impact of educational interventions. Methods Participants from Osaka Metropolitan University, Osaka City University, and Osaka Prefecture University completed questionnaires before and after receiving educational materials, including cartoons and a video featuring medical professionals. We compared the correct answer rates for knowledge-related questions and evaluated changes in behavioral characteristics and attitudes toward HPV vaccination and cervical cancer screening before and after distributing the educational materials.
View Article and Find Full Text PDFInt J Womens Health
January 2025
Department of Gynecology, Hebei Petro China Center Hospital, Langfang, People's Republic of China.
Objective: To analyze the relationship and predictive value of Netrin-1 expression and ultrasonic blood flow parameters with the severity of cervical intraepithelial neoplasia (CIN).
Methods: A retrospective analysis was performed on 115 patients diagnosed with CIN and 37 patients with chronic cervicitis, all of whom underwent surgical intervention. The expression levels of Netrin-1 were evaluated through immunohistochemical staining and quantitative fluorescence PCR.
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