AI Article Synopsis
- * Researchers studied how vitamin C, an antioxidant, affects nicotine's genotoxic effects in mice using specific tests to measure DNA damage.
- * Mice treated with vitamin C 24 hours before being exposed to nicotine showed significant protection against DNA damage caused by nicotine.
Article Abstract
Nicotine has been reported to cause acute toxicity and to present long-term risks, such as chromosomal damage and genetic instability. The genotoxicity of nicotine may be mediated partly by an oxidative mechanism. We have evaluated the effects of the antioxidant vitamin C on nicotine-induced genotoxicity in mice. The comet assay and the micronucleus test were used to assess the effects of nicotine (15mg/kg) at different exposure times (2, 4, and 24h in the comet assay; 24h in the micronucleus test). Pretreatment with vitamin C 24h before nicotine exposure strongly protected mice against nicotine-induced DNA damage.
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| http://dx.doi.org/10.1016/j.mrgentox.2012.01.008 | DOI Listing |
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