Stroke has been identified as the second leading cause of death worldwide. Stroke is a focal neurologic deficit caused by a change in cerebral circulation. The use of animal models in recent years has improved our understanding of the physiopathology of this disease. Rats and mice are the most commonly used stroke models, but the demand for larger models, such as rabbits and even nonhuman primates, is increasing so as to better understand the disease and its treatment. Although the basic mechanisms of stroke are nearly identical among mammals, we here discuss the differences between the human encephalon and various animals. In addition, we compare common surgical techniques used to induce animal models of stroke. A more complete anatomic knowledge of the cerebral vessels of various model species is needed to develop more reliable models for objective results that improve knowledge of the pathology of stroke in both human and veterinary medicine.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155396 | PMC |
Publication Analysis
Top Keywords
Similar Publications
Identification and Construction of a R-loop Mediated Diagnostic Model and Associated Immune Microenvironment of COPD through Machine Learning and Single-Cell Transcriptomics.
Inflammation
January 2025
Department of Geriatrics, Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China.
Chronic obstructive pulmonary disease (COPD) is a prevalent chronic inflammatory airway disease with high incidence and significant disease burden. R-loops, functional chromatin structure formed during transcription, are closely associated with inflammation due to its aberrant formation. However, the role of R-loop regulators (RLRs) in COPD remains unclear.
View Article and Find Full Text PDFManagerial factors affecting milking-abilities of Holstein cattle under intensive production system in Egypt.
Trop Anim Health Prod
January 2025
Department of Animal Production, Faculty of Agriculture, Menoufia University, Shibin Al Kawm, Egypt.
This article aims to explore milking-ability criteria of Holstein dairy cattle under intensive production system in Egypt and investigate some managerial factors that influence them in dairy farms. The data obtained from five herds belong to a commercial intensive production system farm, Egypt. Data included 3509 records.
View Article and Find Full Text PDFAssessing Mitigation Translocation as a Tool to Reduce Human-great Horned owl Conflicts.
Environ Manage
January 2025
United States Department of Agriculture, Animal Plant Health Inspection Service, Wildlife Services, Fort Collins, CO, USA.
The great horned owl (Bubo virginianus) is a generalist predator that inhabits wide-ranging territories that are relatively stable throughout the year. These owls are also involved in a variety of human-owl conflicts, including killing of domestic poultry, predating colonially nesting seabirds and shorebirds, and pose a hazard to safe aircraft operations. Managing these conflict situations presents unique challenges as great horned owls are nocturnally active and occupy a wide range of habitats.
View Article and Find Full Text PDFIron Chelation Prevents Age-Related Skeletal Muscle Sarcopenia in Klotho Gene Mutant Mice, a Genetic Model of Aging.
J Cachexia Sarcopenia Muscle
February 2025
Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA.
Background: A decline in skeletal muscle mass and function known as skeletal muscle sarcopenia is an inevitable consequence of aging. Sarcopenia is a major cause of decreased muscle strength, physical frailty and increased muscle fatigability, contributing significantly to an increased risk of physical disability and functional dependence among the elderly. There remains a significant need for a novel therapy that can improve sarcopenia and related problems in aging.
View Article and Find Full Text PDFA scoping review evaluating the current state of gut microbiota and its metabolites in valvular heart disease physiopathology.
Eur J Clin Invest
January 2025
Department of Cardiology, Bern University Hospital, Inselspital, Bern, Switzerland.
Background: The human microbiome is crucial in regulating intestinal and systemic functions. While its role in cardiovascular disease is better understood, the link between intestinal microbiota and valvular heart diseases (VHD) remains largely unexplored.
Methods: Peer-reviewed studies on human, animal or cell models analysing gut microbiota profiles published up to April 2024 were included.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!