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A dose escalation study to evaluate the safety of an aerosol BCG infection in previously BCG-vaccinated healthy human UK adults.
Front Immunol
November 2024
The Jenner Institute, University of Oxford, Oxford, United Kingdom.
Introduction: Tuberculosis (TB) is the leading cause of death worldwide from a single infectious agent. Bacillus Calmette-Guérin (BCG), the only licensed vaccine, provides limited protection. Controlled human infection models (CHIMs) are useful in accelerating vaccine development for pathogens with no correlates of protection; however, the need for prolonged treatment makes an unethical challenge agent.
View Article and Find Full Text PDFRandomized trial of BCG in healthcare workers to reduce absenteeism during the COVID-19 pandemic in sub-Saharan Africa.
Trans R Soc Trop Med Hyg
November 2024
Bandim Health Project, Guinea-Bissau.
Background: We tested whether providing BCG vaccine to healthcare workers (HCWs) could reduce non-planned absenteeism and thereby reduce the potential impact of the COVID-19 pandemic on healthcare systems in Africa.
Methods: We conducted a multicenter, single-blinded, placebo-controlled randomized trial in Guinea-Bissau and Mozambique between December 2020 and June 2022. Participants were randomized 1:1 to BCG vaccine or placebo (saline) and followed by biweekly telephone calls for 6 mo.
Evaluating the effect of BCG vaccination for non-specific protection from infection in senior citizens during the COVID-19 pandemic: A randomised clinical trial.
J Infect
December 2024
Bandim Health Project, Open Patient Data Explorative Network (OPEN), Department of Clinical Research, University of Southern Denmark, Odense, Denmark; Danish Institute for Advanced Study, University of Southern Denmark, Odense, Denmark.
Objectives: The Bacillus Calmette-Guérin (BCG) vaccine may induce non-specific protection against unrelated infections. We tested the effect of BCG on the risk of infections among Danish senior citizens.
Methods: Single-blinded randomised controlled trial including 1676 volunteers >65 years.
Bacillus Calmette-Guérin vaccination induces a trained innate immunity phenotype in adults over 50 years of age: A randomized trial in Guinea-Bissau.
Vaccine
December 2024
Bandim Health Project, Department of Clinical Research, University of Southern Denmark and Odense University Hospital, Studiestræde 6, 1455 Copenhagen C, Denmark; Danish Institute for Advanced Study, University of Southern Denmark, Fioniavej 34, 5230 Odense, Denmark.
Article Synopsis
- BCG (Bacillus Calmette-Guérin) has shown non-specific immune benefits against infections, and this study investigates its effects in older adults in a TB-endemic area.
- A single-blinded trial in Guinea-Bissau involved 40 adults over 50, with half receiving BCG and the other half a placebo, measuring cytokine production after vaccination.
- Results showed that BCG improved immune responses, particularly in those previously exposed to TB, indicating its potential for enhancing immunity in older populations and warranting further research.
The safety of overdose and repeat administrations of BCG Danish strain 1331 vaccine in calves and pregnant heifers.
Heliyon
July 2024
Animal and Plant Health Agency (APHA), Addlestone, Surrey, KT15 3NB, UK.
Bovine tuberculosis (bTB), caused by infection, is a zoonotic disease in cattle that represents a significant ongoing challenge to cattle farming productivity and the livelihoods of livestock farmers in the UK. Vaccination of cattle with BCG could directly target the ability of to proliferate within vaccinates, restricting bTB pathogenesis and onward disease transmission, and represent a step change in the tools available to help control bTB in farmed cattle. A Marketing Authorisation (MA) is required before a cattle BCG vaccine could be sold and supplied as a veterinary medicine within the UK and this requires comprehensive data supporting vaccine quality, efficacy and, most importantly, its safety.
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