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The porous borders of the protein world. | LitMetric

The porous borders of the protein world.

Structure

Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, USA.

Published: February 2012

AI Article Synopsis

  • Fold switching is important for the evolution of new protein structures and their functions.
  • He et al. demonstrate in their research that a significant change in protein shape can happen through various mutation routes.
  • Their findings highlight the flexibility and complexity of protein evolution.

Article Abstract

Fold switching may play a role in the evolution of new protein folds and functions. He et al., in this issue of Structure, use protein design to illustrate that the same drastic change in a protein fold can occur via multiple different mutational pathways.

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Source
http://dx.doi.org/10.1016/j.str.2012.01.015DOI Listing

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