In many states of the US, the total maximum daily load program has been widely developed for watershed water quality restoration and management. However, the total maximum daily load is often represented as an average daily pollutant load based on average long-term flow conditions, and as such, it does not adequately describe the problems they aim to address. Without an adequate characterization of water quality problems, appropriate solutions cannot be identified and implemented. The total maximum daily load approach should consider adequate water quality characterizations based on overall flow conditions rather than on a single flow event such as average daily flow. The Load Duration Curve, which provides opportunities for enhanced pollutant source and best management practice targeting both in the total maximum daily load development and in water quality restoration efforts, has been used for the determination of appropriate total maximum daily load targets. However, at least 30 min to an hour is needed for unskilled people based on our experiences to generate the Load Duration Curve using a desktop-based spreadsheet computer program. Therefore, in this study, the Web-based Load Duration Curve system (https://engineering.purdue.edu/∼ldc/) was developed and applied to a study watershed for an analysis of the total maximum daily load and water quality characteristics in the watershed. This system provides diverse options for Flow Duration Curve and Load Duration Curve analysis of a watershed of interest in a brief time. The Web-based Load Duration Curve system is useful for characterizing the problem according to flow regimes, and for providing a visual representation that enables an easy understanding of the problem and the total maximum daily load targets. In addition, this system will be able to help researchers identify appropriate best management practices within watersheds.
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http://dx.doi.org/10.1016/j.jenvman.2011.11.012 | DOI Listing |
Alzheimers Dement
December 2024
University of Rochester School of Medicine & Dentistry, Rochester, NY, USA.
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by neuronal dysfunction leading to decreased memory and cognitive function. AD research has largely focused on the potential pathogenic role of two disease hallmarks: amyloid beta and phosphorylated tau. However, pharmacological interventions targeting these disease hallmarks have met with limited clinical trial success.
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December 2024
MRC Unit for Lifelong Health and Ageing at UCL, London, United Kingdom.
Background: Dementia-related biomarkers can detect pathology years before clinical diagnostic criteria are met. Understanding the relationship between biomarkers and early cognitive changes is crucial as disease-modifying therapies may have maximum benefits when delivered early. We aimed to demonstrate the utility of remote computerised cognitive tests in a large cohort of cognitively normal older individuals, comparing these to standard in-person assessments and investigating their associations with biomarkers.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
National Center for Mental Health, Seoul, Korea, Republic of (South).
Background: The study aimed to evaluate the validity of the Korean version of the University of California San Diego Performance-based Skills Assessment, Validation of Intermediate Measures (K-UPSA-2-VIM) in patients with dementia (D), Mild cognitive impairment (MCI), cognitive normal control group (CN), and explore the usefulness of the instrument as a measure of ADL in older adults with cognitive disorder.
Method: Study participants were 25 patients with D, 43 patients with MCI, 111 controls with CN group, respectively. For cognitive assessment, Mini Mental State Examination (K-MMSE-2), Consortium to Establish a Registry for Alzheimer's Disease neuropsychological battery (CERAD-K-NP), Clinical Dementia Rating (CDR) were used.
J Indian Prosthodont Soc
January 2025
Department of Epidemiology, College of Medicine, University of Cincinnati, Ohio, USA.
Aims: To compare the accuracy of marginal fit of CAD-CAM endocrown with two different preparation forms, i.e., endocrown with ferrule and endocrown without ferrule.
View Article and Find Full Text PDFShock
December 2024
Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA.
Background: Loss of muscle mass and strength in patients who have experienced severe burns is dramatic and associated with subsequent functional impairment. Past work has shown that exercise and oxandrolone, an anabolic steroid, individually improve muscle function and muscle mass in severely burned patients. This study aims to evaluate the effect of oxandrolone treatment combined with resistance exercise on muscle atrophy and investigate the protein synthesis and mitochondrial biogenesis pathways in a hindlimb suspension model.
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