During manually performed exercise, ECG revealed silent myocardial ischemia-related ST segment depression in 62 patients with atherosclerosis obliterans in the lower limbs in the absence of evident signs of coronary abnormalities. The patients displayed decreased cardiac output, elevated total peripheral resistance, structural and functional alterations in the end blood flow system, and diminished exercise tolerance as compared to healthy subjects and atherosclerosis obliterans patients with negative loading tests. The aforementioned abnormalities were also revealed in subjects suffering from atherosclerosis obliterans in the lower limbs and documented coronary heart disease.
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