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Hyperoxia-Induced Secondary Respiratory Failure in a Systemic Ischaemia-Reperfusion Injury.
Adv Exp Med Biol
October 2024
Kindai University Faculty of Medicine, Osaka, Japan.
Article Synopsis
- - Recent studies show that breathing pure oxygen (100% O) after cardiac arrest can harm organ function, highlighting the need for careful monitoring of oxygen levels to avoid injury.
- - In a study on rats, those given 100% O showed higher lung injury (measured by wet-to-dry weight ratio) and significant differences in blood gas parameters compared to those given 30% O and healthy controls.
- - The alveolar-arterial oxygen difference (AaDO) strongly correlated with lung injury, suggesting AaDO could serve as a valuable, non-invasive tool for assessing hyperoxic damage in post-cardiac arrest situations.
COMBINATION OF HYPEROXYGENATION AND TARGETED TEMPERATURE MANAGEMENT IMPROVES FUNCTIONAL OUTCOMES OF POST CARDIAC ARREST SYNDROME IRRESPECTIVE OF CAUSES OF ARREST IN RATS.
Shock
June 2024
Department of Biomedical Engineering and Imaging Medicine, Army Medical University, Chongqing, China.
Background: The high mortality rates of patients who are resuscitated from cardiac arrest (CA) are attributed to post cardiac arrest syndrome (PCAS). This study evaluated the effect of hyperoxygenation and targeted temperature management (TTM) on PCAS in rats with different causes of CA. Methods and Results: One hundred sixty-eight Sprague-Dawley rats were equally divided into asphyxial and dysrhythmic groups.
View Article and Find Full Text PDFAssociation of Pediatric Postcardiac Arrest Ventilation and Oxygenation with Survival Outcomes.
Ann Am Thorac Soc
June 2024
Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania.
Adult and pediatric studies provide conflicting data regarding whether post-cardiac arrest hypoxemia, hyperoxemia, hypercapnia, and/or hypocapnia are associated with worse outcomes. We sought to determine whether postarrest hypoxemia or postarrest hyperoxemia is associated with lower rates of survival to hospital discharge, compared with postarrest normoxemia, and whether postarrest hypocapnia or hypercapnia is associated with lower rates of survival, compared with postarrest normocapnia. An embedded prospective observational study during a multicenter interventional cardiopulmonary resuscitation trial was conducted from 2016 to 2021.
View Article and Find Full Text PDFInsufficient oxygen inhalation during cardiopulmonary resuscitation induces early changes in hemodynamics followed by late and unfavorable systemic responses in post-cardiac arrest rats.
FASEB J
July 2023
Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York, USA.
Cardiac arrest (CA) and concomitant post-CA syndrome lead to a lethal condition characterized by systemic ischemia-reperfusion injury. Oxygen (O ) supply during cardiopulmonary resuscitation (CPR) is the key to success in resuscitation, but sustained hyperoxia can produce toxic effects post CA. However, only few studies have investigated the optimal duration and dosage of O administration.
View Article and Find Full Text PDFHyperoxia for accidental hypothermia and increased mortality: a post-hoc analysis of a multicenter prospective observational study.
Crit Care
April 2023
Department of Emergency and Critical Care Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan.
Background: Supraphysiologic oxygen administration causes unfavorable clinical outcomes in various diseases, including traumatic brain injury, post-cardiac arrest syndrome, and acute lung injury. Accidental hypothermia is a critical illness that reduces oxygen demands, and excessive oxygen is likely to emerge. This study aimed to determine whether hyperoxia would be associated with increased mortality in patients with accidental hypothermia.
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