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Prospective piperacillin lymphocyte transformation testing in patients with cystic fibrosis receiving regular and desensitization courses of piperacillin-tazobactam.
J Allergy Clin Immunol Pract
December 2024
MRC Centre for Drug Safety Science, Department of Clinical and Molecular Pharmacology, University of Liverpool, UK. Electronic address:
Background: Piperacillin-tazobactam is used in patients with cystic fibrosis to treat recurrent respiratory infections. Exposure is associated with a high frequency of non-immediate hypersensitivity.
Objective: To assess the applicability of the lymphocyte transformation test (LTT) for the diagnosis of piperacillin hypersensitivity and the influence of desensitization on piperacillin-specific T-cell responses.
[Delayed hypersensitivity reactions to drugs: Group Report of the Drug Allergy Committee of the Mexican College of Clinical Immunology and Allergy (CMICA).].
Rev Alerg Mex
September 2024
Centro Médico Nacional La Raza; Centro Médico San Carlos, Tlaxcala, Tlaxcala, México.
Article Synopsis
- Adverse drug reactions (ADRs) can be classified into Type A (pharmacokinetics-related) and Type B (immune response-related), with Type B reactions being less well-defined and often categorized into immediate and delayed types.
- This review aims to explore the immunological mechanisms behind delayed hypersensitivity reactions to medications, highlighting their complexities.
- Findings discuss the classification, clinical signs, diagnosis, treatment plans, and overall prognosis of delayed hypersensitivity, emphasizing the need for prompt, tailored approaches by healthcare professionals.
The safety of initial single therapeutic dose challenge with a 5-day prolonged drug provocation test in children with a history of low-risk non-immediate reactions to beta-lactam antibiotics.
Allergy Asthma Proc
November 2024
From the Division of Immunology and Allergy, Department of Pediatrics, Selcuk University Medical Faculty, Konya, Turkey and.
Article Synopsis
- The study evaluated a method to test for beta-lactam antibiotic (BLA) allergies in children with a history of low-risk non-immediate reactions (NIR) using a direct single therapeutic dose challenge followed by a prolonged drug provocation test (DPT).
- A total of 109 children participated, with most reporting a reaction to amoxicillin-clavulanic acid; the most common symptom observed was maculopapular exanthema.
- Results indicated that an initial single-dose DPT was safe and effective, with only a small percentage experiencing minor reactions, suggesting this approach can help identify true allergies in children.
Patch testing in non-immediate hypersensitivity to cotrimoxazole: Is it useful?
Contact Dermatitis
December 2024
Dermatology Department, Hospitais da Universidade de Coimbra, Unidade Local de Saúde de Coimbra, Coimbra, Portugal.
Article Synopsis
- Existing research has raised concerns about the effectiveness of patch testing (PT) for detecting drug hypersensitivity specifically related to cotrimoxazole (CTX).
- This study aimed to evaluate how sensitive PT with CTX is for diagnosing non-immediate cutaneous adverse drug reactions (CADR) among patients.
- The results revealed that there were no significant positive reactions to CTX in patch tests, indicating that this testing method may not be reliable for diagnosing CTX-related CADR, signaling a need for careful interpretation by clinicians.
Comparing Skin and Serum Testing to Direct Challenge Outcomes in Children With β-Lactam Allergies.
J Allergy Clin Immunol Pract
November 2024
Department of Clinical Immunology, Perth Children's Hospital, Perth, WA, Australia; Institute for Pediatric Perioperative Excellence, the University of Western Australia, Perth, WA, Australia; Perioperative Medicine Team, Perioperative Care Program, Telethon Kids Institute, Perth, WA, Australia; UWA Medical School, UWA Centre for Child Health Research, the University of Western Australia, Perth, WA, Australia; Department of Emergency Medicine, Perth Children's Hospital, Nedlands, WA, Australia.
Background: There is a scarcity of prospective studies investigating the relative roles of skin prick and intradermal testing, serum specific IgE, and extended oral challenges in diagnosing children with reported β-lactam allergies.
Objective: To determine the sensitivity and specificity of skin testing and serum specific IgE in children with β-lactam allergies, with immediate and nonimmediate historic reactions.
Methods: Four hundred children with parent-reported β-lactam allergies were recruited into an open-label prospective study.
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