Purpose: Acquisition of laser range scans of an organ surface has the potential to efficiently provide measurements of geometric changes to soft tissue during a surgical procedure. A laser range scanner design is reported here which has been developed to drive intraoperative updates to conventional image-guided neurosurgery systems.
Methods: The scanner is optically-tracked in the operating room with a multiface passive target. The novel design incorporates both the capture of surface geometry (via laser illumination) and color information (via visible light collection) through a single-lens onto the same charge-coupled device (CCD). The accuracy of the geometric data was evaluated by scanning a high-precision phantom and comparing relative distances between landmarks in the scans with the corresponding ground truth (known) distances. The range-of-motion of the scanner with respect to the optical camera was determined by placing the scanner in common operating room configurations while sampling the visibility of the reflective spheres. The tracking accuracy was then analyzed by fixing the scanner and phantom in place, perturbing the optical camera around the scene, and observing variability in scan locations with respect to a tracked pen probe ground truth as the camera tracked the same scene from different positions.
Results: The geometric accuracy test produced a mean error and standard deviation of 0.25 ± 0.40 mm with an RMS error of 0.47 mm. The tracking tests showed that the scanner could be tracked at virtually all desired orientations required in the OR set up, with an overall tracking error and standard deviation of 2.2 ± 1.0 mm with an RMS error of 2.4 mm. There was no discernible difference between any of the three faces on the lasers range scanner (LRS) with regard to tracking accuracy.
Conclusions: A single-lens laser range scanner design was successfully developed and implemented with sufficient scanning and tracking accuracy for image-guided surgery.
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http://dx.doi.org/10.1118/1.3675397 | DOI Listing |
ACS Sens
January 2025
Research Institute for Light-induced Acceleration System (RILACS), Osaka Metropolitan University, 1-2 Gakuencho, Nakaku, Sakai, Osaka 599-8570, Japan.
The unique characteristics of biological structures depend on the behavior of DNA sequences confined in a microscale cell under environmental fluctuations and dissipation. Here, we report a prominent difference in fluorescence from dye-modified single-stranded DNA in a light-induced assembly of DNA-functionalized heterogeneous probe particles in a microwell of several microliters in volume. Strong optical forces from the Mie scattering of microparticles accelerated hybridization, and the photothermal effect from the localized surface plasmons in gold nanoparticles enhanced specificity to reduce the fluorescence intensity of dye-modified DNA to a few %, even in a one-base mismatched sequence, enabling us to clearly highlight the single nucleotide polymorphisms in DNA.
View Article and Find Full Text PDFJAMA Ophthalmol
January 2025
Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, China.
Importance: After cataract surgery, postoperative residual astigmatism can influence a patient's visual quality and satisfaction. Finding ways to minimize this astigmatism is important.
Objective: To compare the clinical outcomes of femtosecond laser arcuate keratotomy (FSAK) and toric intraocular lens (TIOL) implantation for astigmatism correction in patients undergoing femtosecond laser-assisted cataract surgery.
Nature
January 2025
Institute of Physics, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.
The integrated frequency comb generator based on Kerr parametric oscillation has led to chip-scale, gigahertz-spaced combs with new applications spanning hyperscale telecommunications, low-noise microwave synthesis, light detection and ranging, and astrophysical spectrometer calibration. Recent progress in lithium niobate (LiNbO) photonic integrated circuits (PICs) has resulted in chip-scale, electro-optic (EO) frequency combs, offering precise comb-line positioning and simple operation without relying on the formation of dissipative Kerr solitons. However, current integrated EO combs face limited spectral coverage due to the large microwave power required to drive the non-resonant capacitive electrodes and the strong intrinsic birefringence of LiNbO.
View Article and Find Full Text PDFSci Rep
January 2025
Accelerator Operations and Technology Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA.
The pursuit to operate photocathodes at high accelerating gradients to increase brightness of electron beams is gaining interests within the accelerator community, particularly for applications such as free electron lasers (FEL) and compact accelerators. Cesium telluride (CsTe) is a widely used photocathode material and it is presumed to offer resilience to higher gradients because of its wider band gap compared to other semiconductors. Despite its advantages, crucial material properties of CsTe remain largely unknown both in theory and experiments.
View Article and Find Full Text PDFSci Rep
January 2025
Thin Films and Nanoscience Laboratory, Department of Physics, Tripura University, Suryamaninagar, 799022, Tripura, India.
Layer-by-Layer (LbL) technique is the simplest and inexpensive method for preparartion of nano-dimensional thin films for tailoring material behavior having wide range of applications including sensors. Here, spectroscopic behavior of two laser dyes Acriflavine (Acf) and Rhodamine B (RhB) assembled onto LbL films have been investigated. It has been observed that both Acf and RhB form stable LbL films.
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