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Minimal methimazole exposure-induced fatal pancytopenia.
BMJ Case Rep
January 2025
Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
This case highlights that refractory pancytopenia leading to death can occur with methimazole treatment even at a very low cumulative dose and after a very short duration of exposure. In addition, the standard treatments to correct the pancytopenia may not be effective and a bone marrow transplant may be required. Current American Thyroid Association guidelines do not recommend routine monitoring of the complete blood count in patients receiving thionamides because of the rapidity of the onset of agranulocytosis and the lack of positive evidence that such monitoring would be useful.
View Article and Find Full Text PDFAnalysis of the Top Articles and Authors of the Journal of Orthopaedic Trauma and Bibliometric Comparison of Impact Factors of Orthopaedic Surgery Journals.
J Orthop Trauma
January 2025
Department of Orthopaedic Surgery, Medical City Denton, 3535 S Interstate 35, Denton, TX 76210, United States.
Objectives: To determine the top 100 cited authors and the top 20 articles in the Journal of Orthopaedic Trauma (JOT) and compare its impact factor to orthopaedic and non-orthopaedic surgery literature.
Design: Review.
Methods: The Web of Science database was used to determine the top 100 cited authors and top 20 cited articles that originated in JOT from 1995 to the present.
Hereditary Transthyretin Amyloidosis in Israel: Genetic Landscape and Clinical Characteristics.
Eur J Neurol
February 2025
Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Background: Hereditary transthyretin (ATTRv) amyloidosis is a rare, adult-onset autosomal-dominant disorder caused by pathogenic variants in the transthyretin (TTR) gene. Data about relevant variants in specific populations and typical initial manifestations may facilitate early diagnosis and treatment. We here describe the genetic landscape of ATTRv amyloidosis in Israel.
View Article and Find Full Text PDFMultimodal machine learning enables AI chatbot to diagnose ophthalmic diseases and provide high-quality medical responses.
NPJ Digit Med
January 2025
Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Chatbot-based multimodal AI holds promise for collecting medical histories and diagnosing ophthalmic diseases using textual and imaging data. This study developed and evaluated the ChatGPT-powered Intelligent Ophthalmic Multimodal Interactive Diagnostic System (IOMIDS) to enable patient self-diagnosis and self-triage. IOMIDS included a text model and three multimodal models (text + slit-lamp, text + smartphone, text + slit-lamp + smartphone).
View Article and Find Full Text PDFDigital Surveillance of Mental Health Care Services in Saudi Arabia: Cross-Sectional Study of National e-Referral System Data.
JMIR Public Health Surveill
January 2025
Department of Health Services Research and Administration, College of Public Health, University of Nebraska Medical Center, Omaha, NE, United States.
Background: Mental illness affects an estimated 25% of the global population, with treatment gaps persisting worldwide. The COVID-19 pandemic has exacerbated these challenges, leading to a significant increase in mental health issues globally. In Saudi Arabia, the lifetime prevalence of mental disorders is estimated at 34.
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