AI Article Synopsis
- CCL2 is a chemokine that plays a role in brain inflammation and impacts lymphocyte entry into brain tissue, but the exact mechanisms are not well understood.
- This study investigates which cell type overproduces CCL2 during T-cell infiltration in the brain across various scenarios and species.
- Findings indicate that CCL2+ astrocytes are involved in T-cell infiltration, with direct contact between T-cells and perivascular astrocytes potentially facilitating lymphocyte movement out of blood vessels into brain tissue.
Article Abstract
CCL2 is a chemokine involved in brain inflammation, but the way in which it contributes to the entrance of lymphocytes in the parenchyma is unclear. Imaging of the cell type responsible for this task and details on how the process takes place in vivo remain elusive. Herein, we analyze the cell type that overexpresses CCL2 in multiple scenarios of T-cell infiltration in the brain and in three different species. We observe that CCL2+ astrocytes play a part in the infiltration of T-cells in the brain and our analysis shows that the contact of T-cells with perivascular astrocytes occurs, suggesting that may be an important event for lymphocyte extravasation.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271104 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030762 | PLOS |
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